Patients with ER-positive Early Breast Cancer with a Low Risk of Tumor Recurrence Can Safely Avoid Chemotherapy
by dr. Johan Indra Lukito
| 05 June 2026
Tumor gene expression tests are widely utilized to assist in adjuvant chemotherapy decisions for patients with early breast cancer (EBC). The OPTIMA (Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis) trial investigates the effectiveness of utilizing the Prosigna (PAM50) gene expression test to guide these critical treatment pathways. By comparing a test-directed treatment strategy against standard chemotherapy followed by endocrine therapy, this study aims to personalize care for patients with high clinical risk ER-positive, HER2-negative EBC, particularly focusing on those with node-positive disease.