Osimertinib Plus Chemotherapy: Better Survival in Patients with Advanced Non-Small Cell Lung Cancer with EGFR Mutations
by dr. Johan Indra Lukito
| 14 January 2026
EGFR (epidermal growth factor receptor)-mutated advanced non-small cell lung cancer (NSCLC) is a subtype of lung cancer caused by changes in the EGFR gene that persistently activate cell growth signals. The FLAURA2 clinical trial was conducted to determine whether combining platinum-pemetrexed chemotherapy with osimertinib, a third-generation EGFR-TKI, could improve outcomes for patients with previously untreated EGFR-mutated advanced NSCLC. This clinical trial compared the efficacy and safety of the combination regimen to osimertinib monotherapy.