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PROVE D3

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    Komposisi:

    Vitamin D3 (cholecalciferol) 1000 IU (25 mcg)

    Sediaan/Kemasan:

    Tablet salut selaput: Dus isi 3 strip x 10 tablet

    Farmakologi:

    Dalam bentuk aktif secara biologi, vitamin D menstimulasi absorpsi kalsium melalui usus, penggabungan kalsium ke dalam osteoid, dan pelepasan kalsium dari jaringan tulang. Dalam usus halus, Cholecalciferol dalam bentuk aktif memicu ambilan kalsium yang cepat dan tertunda. Transpor pasif dan aktif fosfat juga distimulasi. Pada ginjal, vitamin D dalam bentuk aktif menghambat ekskresi kalsium dan fosfat dengan memicu reabsorpsi tubulus. Produksi hormon paratiroid (PTH) di paratiroid dihambat secara langsung oleh bentuk aktif vitamin D secara biologi. Selain itu, sekresi PTH juga dihambat oleh peningkatan ambilan kalsium pada usus halus dengan pengaruh vitamin D yang aktif secara biologi.

    Indikasi:

    Untuk meningkatkan kadar 25(OH)D dalam darah pada pasien dengan kekurangan vitamin D (kadar 25(OH)D serum <30 ng/mL).

    Dosis:

    Dewasa dan anak >12 tahun: 1 tablet, 1 kali sehari, diminum setelah makan.

    Dosis bisa disesuaikan berdasarkan kadar 25-hydroxycholecalciferol [25(OH)D] serum dan tidak melebihi 5000 IU/hari atau menurut petunjuk dokter menurut kebutuhan dan kondisi pasien.

    Kontraindikasi:

    - Hipersensitivitas

    - Hipervitaminosis D

    - Nefrolitiasis atau nefrokalsinosis

    - Penyakit atau kondisi yang menyebabkan hiperkalsemia dan/atau hiperkalsiuria

    - Kerusakan ginjal berat dan gagal ginjal

    Peringatan dan Perhatian:

    - Gangguan fungsi ginjal

    - Sarkoidosis atau penyakit granulomatosa lainnya

    - Selama terapi jangka panjang, kadar kalsium serum dan fungsi ginjal harus dipantau.

    - Dosis total vitamin D3 harus dipertimbangkan dan disesuaikan ketika meresepkan obat ini dengan produk obat lain yang mengandung vitamin D3. - Status kalsium dan asupan makanan pasien secara individu juga harus dipertimbangkan bersamaan dengan memulai penggantian atau terapi vitamin D3.

    - Pemantauan mungkin diperlukan pada pasien dengan peningkatan sensitivitas terhadap terapi vitamin D3.

    - Pasien dengan intoleransi fruktosa, malabsorpsi glukosa-galaktosa atau insufisiensi sucrase-isomaltase sebaiknya tidak minum obat ini.

    - Tidak direkomendasikan untuk anak usia di bawah 12 tahun kecuali atas petunjuk dokter.

    - Tidak boleh digunakan selama kehamilan kecuali jika kondisi klinis wanita membutuhkan pengobatan dengan vitamin D3.

    - Vitamin D3 dan metabolitnya diekskresikan dalam ASI.

    Efek Samping:

    Hiperkalsemia, hiperkalsiuria, pruritus, ruam, urtikaria, reaksi hipersensitivitas, mual, muntah

    Interaksi Obat:

    Infus fosfat, glikosida jantung, diuretik thiazide, metabolit atau analog vitamin D, phenytoin, fenobarbital, primidone, rifampicin, isoniazid, orlistat, paraffin cair, cholestyramine, glucocorticoid, multivitamin dan mineral, calcitonin, etidronate, gallium nitrate, pamidronate, atau plicamycin, garam kalsium, conivaptan, aripiprazole, axitinib, saxagliptin, bile acid sequestrant, penginduksi CYP3A4, deferasirox, minyak mineral, orlistat, sevelamer, tocilizumab.

    PROVE D3

     

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    Composition:

    Vitamin D3 (cholecalciferol) 1000 IU (25 mcg)

    Presentation:

    Film coated tablet: Box of 3 strips x 10 tablets

    Pharmacology:

    In its biologically active form, vitamin D stimulates intestinal calcium absorption, incorporation of calcium into the osteoid, and release of calcium from bone tissue. In the small intestine, it promotes rapid and delayed calcium uptake. The passive and active transport of phosphate is also stimulated. In the kidney, it inhibits the excretion of calcium and phosphate by promoting tubular resorption. The production of parathyroid hormone (PTH) in the parathyroids is inhibited directly by the biologically active form of vitamin D. PTH secretion is inhibited additionally by the increased calcium uptake in the small intestine under the influence of biologically active vitamin D.

    Indications:

    To increase 25(OH)D levels in the blood in patients with a lack of vitamin D (serum 25(OH)D levels <30 ng/mL).

    Dose:

    Adults and children >12 years: 1 tablet, once daily, taken after meals.

    The doses should be adjusted based on serum 25-hydroxycholecalciferol [25(OH)D] levels and not exceed 5000 IU/day, or according to the doctor's instructions according to the needs and conditions of the patient.

    Contraindications:

    - Hypersensitivity

    - Hypervitaminosis D

    - Nephrolithiasis or nephrocalcinosis

    - Diseases or conditions resulting in hypercalcemia and/or hypercalciuria

    - Severe renal damage and renal failure

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    Warnings and Precautions:

    - Iimpairment of renal function

    - Sarcoidosis or other granulomatous disease

    - Long-term treatment, serum calcium levels, and renal function (through measurements of serum creatinine) should be monitored.

    - The total dose of vitamin D3 should be considered and adjusted accordingly when prescribing this drug with other medicinal products containing vitamin D3l.

    - The calcium status and dietary intake of individual patients should also be considered at the same time as starting vitamin D3 replacement or treatment.

    - Monitoring may be necessary in patients with increased sensitivity to vitamin D3 therapy.

    - Patients with fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase insufficiency should not take this medicine.

    - Not recommended for children under 12 years.

    - Should not be used during pregnancy unless a woman's clinical condition requires treatment with Cholecalciferol, with the dose needed to overcome the lack of vitamin D.

    - Vitamin D3 and its metabolites are excreted in breast milk.

     Adverse Reactions:

    Hypercalcemia, hypercalciuria, pruritus, rash, urticaria hypersensitivity reactions, nausea, vomiting

    Drug Interactions:

    Jawab.Phosphate infusion, cardiac glycoside, thiazide diuretic, metabolites of vitamin D3 or vitamin D analogues, phenytoin, fenobarbital, primidone, rifampicin, isoniazid, orlistat, paraffin cair, cholestyramine, glucocorticoid, multivitamin dan mineral, calcitonin, etidronate, gallium nitrate, pamidronate, atau plicamycin, garam kalsium, conivaptan, aripiprazole, axitinib, saxagliptin, bile acid sequestrant, penginduksi CYP3A4, deferasirox, minyak mineral, orlistat, sevelamer, tocilizumab.

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