IFEN
Wednesday, February 13, 2019

IFEN

Branded

 

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Komposisi:

Ibuprofen 200 dan 400 mg

Bentuk sediaan:

Tablet

Farmakologi:

Bekerja sebagai antiinflamasi, analgesik, dan antipiretik melalui penghambatan prostaglandin dengan menghambat enzim cyclooxygenase.

Indikasi:

- IFEN diindikasikan untuk pengobatan simtomatik artritis reumatoid dan osteoartritis, pada fase akut dan untuk pengobatan jangka panjang.

- IFEN juga diindikasikan untuk pengobatan rasa nyeri yang ringan sampai sedang.

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Dosis:

Dewasa :

- artritis reumatoid dan osteoartritis: Sehari 3 - 4 x 1 tablet 200 mg atau 400 mg, disesuaikan dengan kebutuhan masing-masing penderita.

- Nyeri ringan sampai sedang: 200 - 400 mg tiap 4 - 6 jam sesuai kebutuhan.

Kontraindikasi:

- Ulkus peptikum

- Ibu hamil trimester III

- Bronkospasme, alergi rinitis dan urtikaria karena asetosal

- Hipersensitif terhadap ibuprofen

Peringatan dan Perhatian:

- Hindarkan penggunaan pada kehamilan trimester 3 karena dapat menyebabkan penutupan dini duktus arteriosus

- Pemberian bersama dengan NSAID lain

Efek Samping:

Gangguan saluran cerna, gangguan pembekuan darah, gangguan kardiovaskuler, reaksi hipersensitif, gangguan fungsi ginjal.

 

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IFEN

 

Composition:

Ibuprofen 200 mg and 400 mg.

Presentation:

Tablet 200 mg : Box contains 10 strips x 10 tablets Tablet 400 mg : Box contains 10 strips x 10 tablets.

Pharmacology:

Works as an anti-inflammatory, analgesic and antipyretic by inhibiting the activity of cyclooxygenase (COX) enzyme which leads to the formation of prostaglandins.

Indications:

- IFEN is indicated for symptomatic treatment of rheumatoid arthritis and osteoarthritis, in the acute phase and for long-term treatment. - IFEN is also indicated for the treatment of mild to moderate pain.

Contraindications:

- Peptic ulcer - Third trimester of pregnancy - Bronchospasm, allergic to rhinitis and urticaria due to acetosal - Hypersensitivity to ibuprofen.

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Dosage:

Adult: - Rheumatoid arthritis and osteoarthritis: 3-4 x 1 tablet 200 mg or 400 mg/day, adjusted to the needs of each patient. - Mild to moderate pain: 200 - 400 mg every 4 - 6 hours as needed.

Warning and Precautions:

- Ifen should be avoided in the third trimester of pregnancy because it may cause premature closure of the ductus arteriosus. - Concomitant use with other NSAIDs.

Adverse events:

Gastrointestinal disorders, blood clotting disorders, cardiovascular disorders, hypersensitivity reactions, impaired kidney function.

Drugs Interaction:

- Use with acetylsalicylic acid or other NSAIDs may result in possible additive adverse side effects. - Use with acetaminophen, may increase the risk of adverse renal effect. - Use with anticoagulants may increase the risk of GI adverse events (e.g., bleeding). - Use with hypoglycemic agents (oral agents and insulin) may increase the risk of hypoglycaemia. - Use with antihypertensives may interfere with circulatory control. - Use with diuretics may reduce the diuretic effect. - Use with methotrexate may increase the risk of methotrexate toxicity. - Use with lithium may increase the risk of lithium toxicity.

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