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    Komposisi:

    Amikacin

    Bentuk sediaan:

    Vial 2 mL 250 mg : dus isi 10 vial 
    Vial 2 mL 500 mg : dus isi 10 vial

    Farmakologi:

    Antibiotik golongan aminoglikosida yang bekerja dengan cara menghambat sintesis protein di ribosom bakteri. Eliminasi: 84% melalui ginjal. Waktu paruh eliminasi 2 jam.

    Indikasi:

    Septikemia, infeksi saluran napas, infeksi tulang dan sendi, infeksi susunan saraf pusat, infeksi intraabdomen, infeksi luka bakar, infeksi pascabedah, infeksi saluran kemih.

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    Dosis:

    15 mg / kgBB / hari, terbagi dalam 2 - 3 dosis. Diberikan secara intravena.

    Kontraindikasi:

    Hipersensitivitas, pasien dengan riwayat efek samping serius akibat penggunaan amikacin.

    Peringatan dan Perhatian:

    - Bersifat ototoksik, neurotoksik dan nefrotoksik.

    - Dapat mengakibatkan paralisis neuromuskuler.

    - Kategori kehamilan D.

    - Dapat terjadi alergi silang dengan sesama antibiotik aminoglikosida.

    Efek Samping:

    Ototoksik, neurotoksik, nefrotoksik, hipersentitivitas, mual, muntah, sakit kepala, paralisis.

    Interaksi Obat:

    - Pemberian bersamaan dengan obat ototoksik atau obat nefrotoksik harus dihindari. - Pemakaian Amikacin bersamaan dengan diuretik kuat harus dihindari karena dapat menyebabkan dehidrasi dan meningkatkan kadar serum Amikacin.

     

     

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    Composition:

    Amikacin

    Presentation:

    Vial 2 mL 250 mg: box of 10 vials Vial 2 mL 500 mg: box of 10 vials

    Pharmacology:

    Aminoglycoside class antibiotics that work by inhibiting protein synthesis in bacterial ribosomes. Elimination: 84% through the kidneys. Elimination half-life of 2 hours.

    Indications:

    Septicemia, airway infections, bone and joint infections, central nervous system infections, intra-abdominal infections, burns infections, postoperative infections, urinary tract infections.

    Contraindications:

    Hypersensitivity, patients with a history of serious side effects due to the use of amikacin.

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    Dosage:

    15 mg / kg / day, divided into 2-3 doses. Given intravenously.

    Warning and Precautions:

    - Are ototoxic, neurotoxic and nephrotoxic. - Can result in neuromuscular paralysis. - Category of pregnancy D. - Cross allergies can occur with fellow aminoglycoside antibiotics.

    Adverse events:

    Ototoxic, neurotoxic, nephrotoxic, hypersensitivity, nausea, vomiting, headache, paralysis.

    Drugs Interaction:

    - Giving together with ototoxic drugs or nephrotoxic drugs should be avoided. - The use of Amikacin together with strong diuretics should be avoided because it can cause dehydration and increase Amikacin serum levels.

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