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    Komposisi:

    Lansoprazole 30 mg

    Bentuk sediaan:

    Kapsul 30 mg, 1 dus: 2 strip x 10 kapsul.

    Farmakologi:

    Merupakan penghambat pompa proton yang bekerja menekan sekresi asam lambung secara spesifik dengan menghambat H+K+ATP- ase dari sel-sel parietal mukosa lambung. Cepat diabsorbsi, kadar obat serum dicapai 1,5 jam setelah diminum. Bioavailabilitas tinggi (80-90%), sehingga sekresi asam lambung dapat segera dihambat. Dimetabolisme dalam hati dan diekskresikan terutama dalam feses, hanya 15-30% dari dosis diekskresikan dalam air seni. Waktu paruh dicapai sekitar 1,4 jam tetapi masa kerjanya lebih panjang. Sekitar 97% terikat protein plasma. Bersihan ginjal menurun pada pasien usia lanjut dan penderita gangguan hati.

    Indikasi:

    Ulkus duodenum, ulkus gaster jinak, refluks esofagitis.

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    Dosis:

    - Ulkus duodenum/refluks esofagitis: 1 kapsul sehari selama 4 minggu.

    - Ulkus gaster jinak: 1 kapsul sehari selama 8 minggu

    - Pasien lanjut usia, pasien dengan gangguan fungsi hati dan ginjal: tidak diperlukan penyesuaian dosis. Jangan melebihi 30 mg/hari.

    Lancid sebaiknya diminum pagi hari sebelum makan.

    Kontraindikasi:

    Hipersensitif terhadap Lanzoprazole

    Peringatan dan Perhatian:

    - Hati-hati pada penggunaan jangka panjang

    - Wanita hamil dan menyusui: belum didapatkan data yang cukup tentang penggunaannya pada wanita hamil. Sebaiknya lansoprazole tidak digunakan selama hamil kecuali jika benar-benar diperlukan.

    - Pada ibu yang sedang menyusui harus dipertimbangkan, apakah pemakaian obat yang dihentikan atau berhenti menyusui, tergantung pada pentingnya obat bagi si ibu.

    - Keamanan dan efektifitas pada anak-anak belum dibuktikan.

    Efek Samping:

    - Sakit kepala (lebih dari 1% kasus), diare.

    - Efek samping lain (kurang dari 1 %): Reaksi mirip anafilaksis, asthenia, kandidiasis, nyeri dada (tidak spesifik), edema, demam, sindrom flu, halitosis, infeksi (tidak spesifik), malaise

    - Sistem Kardiovaskuler: angina, gangguan serebrovascular, infark miokard, palpitasi, syok (kegagalan sirkulasi)

    - Sistem Pencernaan: melena, gangguan pencernaan, hematemesis, pendarahan rektum, kolitis ulserativa

    - Sistem Endokrin diabetes mellitus, goiter

    - Sistem Hematologik and Limfatik : pansitopenia, trombotik trombositopenia purpura

    - Gangguan Metabolik: gout; Sistem Muskuloskeletal: artritis, mialgia

    - Sistem Saraf : dizziness, halusinasi, hemiplegia, penurunan libido, gangguan berpikir

    - Sistem Pernapasan : asma, pneumonia; Kulit : jerawat, alopesia, rash

    - Panca-Indera : gangguan pendengaran, gangguan penglihatan, gangguan pengecapan

    - Sistem Urogenital : haid abnormal, hematuria, impotensi. Sebagian besar kasus hematologi tidak diketahui secara jelas hubungannya dengan lansoprazole.

     

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    DIGEST

     

    Composition:

    30 mg lansoprazole.

    Presentation:

    30 mg lansoprazole capsule, box: 2 strips x 10 capsules.

    Pharmacology:

    s a proton pump inhibitor that works to suppress gastric acid secretion specifically by inhibiting H + K + ATP-ase from parietal cells of the gastric mucosa. Quickly absorbed, serum drug levels are reached 1.5 hours after taking the medicine. It has high bioavailability (80-90%), so that the secretion of stomach acid can be immediately inhibited. Metabolized in the liver and excreted mainly in feces, only 15-30% of the dose is excreted in urine. The half-life is around 1.4 hours but the working period is longer. About 97% is bound to plasma proteins. Kidney clearance decreases in elderly patients and patients with liver disorders.

    Indications:

    Duodenal ulcer, benign gastric ulcer, reflux esophagitis.

    Contraindications:

    Hypersensitivity to lanzoprazole.

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    Dosage:

    - Duodenal ulcer / reflux esophagitis: 1 capsule daily for 4 weeks. - Benign gastric ulcer: 1 capsule daily for 8 weeks - Elderly patients, patients with impaired liver and kidney function: no dose adjustment is needed. Do not exceed 30 mg / day. Digest should be taken in the morning before meals.

    Warning and Precautions:

    - Be careful of long-term use. - Pregnant and breastfeeding women: there are not enough data about its use in pregnant women. Lansoprazole should not be used during pregnancy unless absolutely necessary. - In mothers who are breastfeeding should be considered, whether the use of drugs that are stopped or stop breastfeeding, depending on the importance of the drug for the mother. - Safety and effectiveness in children has not been proven.

    Adverse events:

    - Headache (more than 1% of cases), diarrhea. - Other side effects (less than 1%): Reactions similar to anaphylaxis, asthenia, candidiasis, chest pain (not specific), edema, fever, flu syndrome, halitosis, infection (non-specific), malaise - Cardiovascular system: angina, cerebrovascular disorders, myocardial infarction, palpitations, shock (circulatory failure) - Digestive system: melena, digestive disorders, hematemesis, rectal bleeding, ulcerative colitis - Endocrine diabetes mellitus, goiter system - Hematological and lymphatic system: pancytopenia, thrombotic thrombocytopenia purpura - Metabolic Disorders: gout; Musculoskeletal system: arthritis, myalgia - Nervous system: dizziness, hallucinations, hemiplegia, decreased libido, thinking disorders - Respiratory system: asthma, pneumonia; Skin: acne, alopecia, rash - Five-senses: hearing loss, visual impairment, taste disorder - Urogenital system: abnormal menstruation, hematuria, impotence. Most haematological cases have not been clearly identified with lansoprazole.

    Drugs Interaction:

    -

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