FEROFORT

 

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Komposisi:

Ferronyl 84,7 mg

Asam askorbat 150 mg

Asam folat 1 mg

Vitamin B12 10 mg

Vitamin B1 3 mg

Vitamin B2 3 mg

Vitamin B6 5 mg

Niacinamide 30 mg

Calcium pantothenate 15 mg

ZnSO4. H2O 41,2 mg (ekivalen dengan elemen Zn) 15 mg

Lysine 50 mg

Bentuk sediaan:

Kaplet salut selaput

Farmakologi:

FEROFORT adalah preparat besi oral dosis tinggi dengan suplemen vitamin B kompleks, seng dan asam amino esensial lisin. Besi adalah elemen yang sangat dibutuhkan dalam pembentukan hemoglobin dan proses oksidasi jaringan. Besi terutama diabsorpsi di duodenum dan jejunum. Selanjutnya besi disimpan dalam tubuh sebagai transferin dan hemosiderin; 30% pada hati, 30% pada sumsum tulang dan sisanya terdapat dalam limpa dan otot. Asam askorbat berperan penting dalam sintesa kolagen dan materi antar sel. Asam askorbat membantu absorpsi dari zat besi. Suplemen vitamin B kompleks dalam jumlah kebutuhan sehari-hari berguna pada keadaan defisiensi relatif akibat meningkatnya kebutuhan, tidak cukupnya asupan, atau akibat gangguan absorpsi nutrisi. Vitamin B kompleks diabsorbsi pada saluran pencernaan, menjalani sirkulasi enterohepatik, terutama disimpan dalam hati dan dibuang melalui urin. Vitamin tersebut juga didistribusikan dalam air susu. Asam folat direduksi dalam tubuh menjadi tetrahidrofolat, yang merupakan koenzim dalam berbagai proses metabolik termasuk sintesa nukleotida purin dan pirimidin. Tiamin HCl berperan penting dalam transformasi energi dan membran serta konduksi saraf. Bentuk aktif terfosforilasi dari riboflavin penting dalam reaksi metabolik oksidatif/reduktif sebagai koenzim. Piridoksin HCl berperan dalam metabolisme asam amino, karbohidrat dan lemak. Selain itu piridoksin dibutuhkan dalam pembentukan hemoglobin. Sianokobalamin penting untuk fungsi normal metabolisme sel dan mempengaruhi pembentukan mielin. Niasin berperan dalam reaksi perpindahan elektron dalam rantai pernapasan, pembentukan sel dan regulasi gen. Seng adalah mineral yang menstimulasi aktivitas enzim. Seng diabsorpsi di saluran pencernaan dan dieksresikan terutama melalui tinja. Lisin sebagai asam amino esensial.

Indikasi:

Suplemen pencegahan anemia terutama pada wanita hamil dan menyusui.

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Dosis:

1 kaplet sehari, diberikan bersama makanan atau sehabis makan.

Kontraindikasi:

Penderita hemokromatosis primer dan siderosis akibat transfusi

Hipersensitif

Peringatan dan Perhatian:

Tidak untuk pasien anemia hemolitik tanpa defisiensi zat besi. Pemberian jangka panjang dalam dosis tinggi harus dihindari kecuali pada penderita dengan perdarahan terus-menerus, perdarahan haid yang berlebihan atau kehamilan berulang.

Asam askorbat harus hati-hati pada pasien dengan hiperoksaliuria. Zat besi dapat menyebabkan feses berwarna hitam tetapi tidak berbahaya dan hilang bila pemakaian dihentikan.

Efek Samping:

Dapat menimbulkan gangguan saluran pencernaan, terutama rasa mual, nyeri ulu hati, diare atau konstipasi.

Interaksi Obat:

Besi dapat menurunkan khasiat fluorokuinolon, levodopa, metildopa, penisilamin dan tetrasiklin. Suplemen mengandung magnesium atau antasida dapat menurunkan absorpsi besi. Asam askorbat dan asam sitrat dapat meningkatkan absorbs besi.

Ferofort

 

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Composition:

Ferronyl 84,7 mg

Ascorbic Acid 150 mg

Folic Acid 1 mg

Vitamin B12 10 mg

Vitamin B1 3 mg

Vitamin B2 3 mg

Vitamin B6 5 mg

Niacinamide 30 mg

Calcium pantothenate 15 mg

ZnSO4. H2O 41,2 mg (equivalent to elemenal Zn) 15 mg

Lysine 50 mg

Presentation:

Film coated caplet

Pharmacology:

FEROFORT is an oral iron preparation with dietary supplements of B-complex vitamins, zinc and lysine. Iron is an essential constituent of the body needed for haemoglobin formation and for the oxidative process of the living tissues. Iron is mainly absorbed in duodenum and jejunum. Following absorption of iron is mostly stored in the body as transferrin and hemosiderin; 30% is in the liver, 30% occurs in the bone marrow, and the rest is found in the spleen and muscles. Ascorbic acid is essential for the synthesis of collagen and intercellular material. Ascorbic acid helps to absorb iron. Dietary supplemental amounts of B complex vitamins are useful in relative nutritional deficiencies due to increased requirements, inadequate intake, or impaired absorption of nutrients. B complex vitamins are absorbed from the gastrointestinal tract, undergo enterohepatic circulation, mainly stored in the liver and eliminated in the urine. They are also distributed into breast milk. Folic acid is reduced in the body to tetrahydrofolate, which is coenzyme for various metabolic process including synthesis of purine and pyrimidine nucleotides. Thiamine HCl has essential roles in energy transformation and membrane and nerve conduction. The active, phosphorylated forms of riboflavine are necessary in oxidative/reductive metabolic reactions as coenzymes. Pyridoxine HCl is involved in metabolism of amino acid, carbohydrate and fat. It is also required for the formation of haemoglobin. Cyanocobalamin is essential for normal function in the metabolism of all cells and affects myelin formation. Niacinamide is involved in electron transfer reactions in the respiratory chain and used in the cells energy production, biochemistry and gene regulation. Zinc is an essential trace element which stimulates the enzymes activities. Zinc is absorbed from GI tract and mainly excreted in the faeces. Lysine is an essential amino acid.

Indications:

FEROFORT is indicated as supplement to prevent iron deficiency anemia especially during pregnancy and lactation.

Dosage:

Adult dosage is 1 caplet daily, with or after meals.

Contraindications:

Contraindicated in patients with primary hypersensitive to drug substance, hemochromatosis and transfusion siderosis.

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Warnings and Precautions:

It is not indicated in hemolytic patients without iron deficiency. Long term high dose administration should be avoided except for patients with continuous bleeding, copious menstrual bleeding or repeated pregnancies.

Ascorbic acid should be given with care to patients with hyoeroxalauria. Iron can cause dark colored feces which is not dangerous and it will disappear if consumption is stopped.

Adverse Reactions:

Iron administration may cause gastrointestinal disturbances, particularly nausea, epigastric pain, diarrhea or constipation.

Drug Interactions:

Iron can reduce clinical effect of fluoroquinolones, levodopa, methyldopa, penicillamine and tetracycline. Compounds containing calcium and magnesium, including antacids may impair the absorption of iron. Ascorbic acid and citric acid increase its absorption.

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