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    Komposisi:

    Cilostazol

    Bentuk sediaan:

    Boks berisi 5 strip @ 10 tablet 50 mg dan 100 mg

    Farmakologi:

    Menghambat PDE, yang menurunkan degradasi cAMP sehingga cAMP meningkat. Peningkatan cAMP ini menurunkan agregrasi trombosit dan terjadi juga vasodilatasi. Selain itu pemberian cilostazol menurunkan proliferasi otot polos pembuluh darah. Absorpsi meningkat dengan pemberian makanan berlemak. T1/2 11 – 13 jam. Kadar mantap tercapai dlm beberapa hari. Ikatan protein 95% – 98%, fraksi bebas meningkat 27% pada pasien gangguan ginjal. Ekskresi 74% urin 20% feses

    Indikasi:

    Klaudikasio intermiten

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    Dosis:

    - 100 mg Citaz 2 kali sehari minimal setengah jam sebelum atau 2 jam setelah makan pagi dan makan malam.

    - Dosis 50 mg bisa diberikan bila Citaz akan diberikan bersama dengan obat-obat yg masuk dalam interaksi.

    - Dianjurkan pemberian selama 12 minggu untuk mendapatkan hasil yang menguntungkan.

    Kontraindikasi:

    - Perdarahan:

    * perdarahan sal. cerna, sal. kemih, paru

    * hemofilia

    * fragilitas pembuluh darah

    - Gagal jantung kongestif derajat 3 dan 4

    - Hipersensitivitas

    - Kehamilan dan menyusui

    Peringatan dan Perhatian:

    Tendensi perdarahan, pemberian bersama antikoagulan atau antiplatelet laing, gangguan hati sedang-berat, gangguan ginjal berat, fraksi bebas meningkat, efek pemberian pada bayi belum diketahui.

    Efek Samping:

    Sakit kepala, diare, palpitasi, dispepsia, edema perifer.

     

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    CITAZ

     

    Composition:

    Cilostazol.

    Presentation:

    Box containing 5 strips @ 10 tablets 50 mg. Box containing 5 strips @ 10 tablets 100 mg.

    Pharmacology:

    Inhibition of PDE which decreases cAMP degradation thus increasing cAMP. Increase in cAMP decreases platelet agregation and causes vasodilation. Cilostazol decreases proliferation of smooth muscle of blood vessel. Fat containing food increase the absorption of cilostazol. Half life: 11-13 hours. Steady state is achieved in a few days. Protein binding 95-98%. Free fraction increases by 27% in patients with renal impairment. Excretion: urine (74%), feces (20%).

    Indications:

    Intermittent claudication.

    Contraindications:

    - Haemorrhage * GI tract, urinary tract, pulmonary * Haemophilia * Fragile blood vessel

    - Grade 3-4 congestive heart failure

    - Hypersensitivity

    - Pregnancy and breastfeeding

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    Dosage:

    - 100 mg, 2 times daily, half an hour before or 2 hours after lunch and dinner.

    - Dose of 50 mg may be given with other drugs that have interaction with cilostazol.

    - It is recommended to be given for 12 weeks to achieve optimal benefit.

    Warning and Precautions:

    Haemorrhage, concomitant use with anticoagulant or other antiplatelet, moderate-severe liver function, severe renal function, increase in free fraction, efficacy in baby is not known.

    Adverse events:

    Headache, diarrhoea, palpitation, dyspepsia, peripheral oedema.

    Drugs Interaction:

    -

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