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    Komposisi:

    Domperidone 10 mg dan 5 mg/5 mL

    Bentuk sediaan:

    Tablet dan sirup

    Farmakologi:

    Efek anti emetik dapat disebabkan oleh kombinasi efek periferal (gastrokinetik) dengan antagonis terhadap reseptor dopamine di kemoreseptor “ trigger zone” yang terletak di luar sawar darah otak di area postrema.

    Indikasi:

    Untuk mual dan muntah akut, mual dan muntah yang disebabkan oleh pemberian levodopa dan bromokriptin lebih dari 12 minggu, pengobatan gejala dispepsia fungsional.

    Anak-anak :untuk mual dan muntah pada kemoterapi kanker dan radioterapi.

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    Dosis:

    Dispepsia fungsional :

    Dewasa : 10 - 20 mg 3 kali sehari dan 10 – 20 mg sekali sebelum tidur malam tergantung respons klinik. Pengobatan jangan melebihi 12 minggu

    Mual dan muntah (termasuk yang disebabkan oleh levodopa dan bromokriptin) :

    Dewasa (termasuk usia lanjut) : 10 – 20 mg sehari, interval waktu 4 - 8 jam.

    Anak-anak (sehubungan kemoterapi kanker dan radioterapi) : 0,2 - 0,4 mg/kg berat badan sehari, dengan interval waktu 4 - 8 jam.

    Obat diminum 15 - 30 menit sebelum makan dan sebelum tidur malam.

    Kontraindikasi:

    Penderita hipersensitif terhadap domperidone.

    Anak-anak (kecuali untuk mencegah mual dan muntah sehubungan kemoterapi kanker dan radioterapi).

    Penderita dengan prolaktinoma tumor hipofise yang mengeluarkan prolaktin.

    Peringatan dan Perhatian:

    Hati-hati penggunaan pada wanita hamil dan menyusui.

    Tidak dianjurkan penggunaan jangka panjang.

    Hati-hati penggunaan pada penderita gangguan fungsi hati dan ginjal.

    Efek Samping:

    Jarang dilaporkan : sedasi, reaksi ekstrapiramidal, distonik parkinson, tardive dyskinesia (pada pasien dewasa dan usia lanjut) dan dapat diatasi dengan obat antiparkinson.

    Peningkatan prolaktin serum sehingga menyebabkan galaktore dan ginekomastia. Mulut kering, sakit kepala, diare, rash kulit, rasa haus, cemas, gatal.

    Interaksi Obat:

    Domperidone mengurangi efek hipoprolaktinemia dari Bromokriptin. Pemberian obat anti kolinergik muskarinik dan analgetik opioid secara bersamaan dapat menghambat efek Domperidone. Antasida dapat menurunkan bioavailabilitas Domperidone.

    DOMET

     

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    Composition:

    Domperidone 10 mg and 5 mg/5 mL

    Presentation:

    Tablet and Syrup

    Pharmacology:

    Antiemetic effect can be achieved by gastro-kinetics peripheral antagonist effect on dopamine receptors on “Chemoreceptor triggered zone” which is positioned in post-rema area outside blood brain barrier.

    Indications:

    For acute nausea and vomiting, nausea and vomiting caused by administration of levodopa and bromocriptine more than 12 weeks, treatment of functional dyspepsia symptoms. Pediatric: for nausea and vomiting caused by cancer chemotherapy and radiotherapy.

    Dosage:

    Functional dyspepsia:

    Adult: 10 - 20 mg three times a day before sleep, depends on clinical response. Medication use do not exceed 12 weeks.

    Nausea and vomiting (including caused by levodopa and bromocriptine):

    Adult (elderly included): 10-20 mg a day, with 4-8 hours interval.

    Pediatric (related to chemotherapy and radiotherapy): 0.2-0.4 mg/kg body weight a day, with 4-8 hours interval.

    Medication is consumed 15-30 minutes before meal and before bedtime

    Contraindications:

    Person who is hypersensitive to domperidone

    Children (except to prevent nausea and vomiting related to chemotherapy and radiotherapy)

    Patients with prolactinoma pituritary tumor which secrets prolactin.

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    Warnings and Precautions:

    Caution for use in pregnant and nursing women

    Long-term use is not recommended

    Caution for use in patients with impaired liver and kidney function.

    Adverse Reactions:

    Rarely reported: sedation, extrapyramidal reactions, dystonic parkinsonism, tardive dyskinesia (in adult and elderly patients) and can be treated with anti-parkinson drugs.

    Increased serum prolactin, causing galactorrhea and gynecomastia. Dry mouth, headache, diarrhea, skin rash, thirst, anxiety, itching.

    Drug Interactions:

    Domperidone reduces hyproprolactinemia effect of bromocryptine. Administration of muscarinic anticholinergic drugs and opioid analgesia drugs altogether can inhibit effect of domperidone. Antacid can reduce domperidone bioavailability.

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