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    Komposisi:

    Spiramycin 125 mg/5 mL

    Bentuk sediaan:

    Sirup

    Farmakologi:

    Menghambat sintesis protein bakteri reversibel

    Indikasi:

    Infeksi saluran napas atas, bronkitis dan infeksi kulit yang disebabkan oleh mikroorganisme yang sensitif terhadap Spiramycin.

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    Dosis:

    - Dewasa:

    500 mg 3x/hari selama 5 hari. Untuk infeksi yang berat dosis dapat dinaikkan sampai 3g/hari.

    - Anak-anak:

    Tablet: 50-100 mg/kg bb/hari

    Sirup: 5-15 mL/hari (1-3 sendok teh) dalam 2-3 dosis terbagi.

    Kontraindikasi:

    Hipersensitif terhadap antibiotik macrolid

    Peringatan dan Perhatian:

    - Pregnancy category B

    - Hati-hati pada penderita gangguan fungsi hati dan ginjal.

    - Belum ada data efektivitas untuk neonatus.

    Efek Samping:

    Jarang: colitis, mual, muntah, nyeri abdominal dan diare.

    Efek samping yang lebih jarang terjadi adalah urtikaria, gatal dan ruam kemerahan.

     

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    Composition:

    Each 5 mL of syrup contains Spiramycin 125 mg. Each tablet contains Spiramycin 500 mg.

    Presentation:

    Box contains 1 bottle of 100 mL syrup : Spiramycin 125 mg/5 mL. Tablet 500 mg : Box contains 3 strips x 10 enteric-coated tablets.

    Pharmacology:

    Reversible bacterial protein synthesis inhibitor.

    Indications:

    Upper respiratory tract infections, bronchitis and skin infections caused by microorganisms that are sensitive to Spiramycin.

    Contraindications:

    Hypersensitivity to macrolid antibiotics.

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    Dosage:

    - Adults: 500 mg 3x/day for 5 days. For severe infections, doses can be increased to 3g/day. - Children: Tablets: 50-100 mg/kgbw/day Syrup: 5-15 mL/day (1-3 teaspoons) divided into 2-3 doses.

    Warning and Precautions:

    - Category B in pregnancy - Beware of patients with liver and kidney function disorders. - There is no effective study for neonates.

    Adverse events:

    Rarely: colitis, nausea, vomiting, abdominal pain and diarrhea. Less common side effects are urticaria, itching and skin rash.

    Drugs Interaction:

    Spiramycin has been reported to inhibit the absorption of carbidopa and decrease levodopa plasma levels.

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