CISPLATIN
Dokter Kalbemed
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CISPLATIN

Generic

 

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Komposisi:

Cisplatin

Sediaan/Kemasan:

Cairan injeksi dalam vial 10 mg/10 mL dan 50 mg/50 mL.

Farmakologi:

Mekanisme kerja: berikatan dengan DNA sehingga menyebabkan hambatan replikasi dan transkripsi.

Ekskresi terutama melalui ginjal (27-43%).

Indikasi:

Kanker testis, kanker ovarium, kanker kandung kemih.

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Dosis:

50-120 mg/m2 setiap 3-4 minggu atau 50 mg/m2 hari 1 & 8 setiap 3-4 minggu atau 15-20 mg/m2 hari 1-5 setiap 3-4 minggu.

Kontraindikasi:

Gangguan fungsi ginjal, mielosupresi, gangguan pendengaran, hipersensitif, kehamilan & laktasi.

Peringatan dan Perhatian:

- Perlu prahidrasi dan pascahidrasi, pemantauan kadar elektrolit, hematologi, fungsi ginjal, saraf, pendengaran, hati.

- Umumnya perlu premedikasi anti-mual muntah.

Efek Samping:

Nefrotoksik, ototoksik, mielosupresi, mual muntah, neurotoksik, reaksi alergi, gangguan elektrolit serum, hiperurisemia.

Interaksi Obat:

Obat-obat yang bersifat nefrotoksik dan ototoksik Penicillamine Bleomycin dan methotrexate Pyridoxine dan hexamethylamine Docetaxel Live vaccine

 

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CISPLATIN

 

Composition:

Cisplatin

Presentation:

Solution for injection in vials of 10 mg/10 mL and 50 mg/50 mL.

Pharmacology:

Mechanism of action: binding to DNA that leads to inhibition of replication and transcription. Cisplatin is excreted primarily in the urine (27-43%).

Indications:

Testicular cancer, ovarian cancer, bladder cancer.

Contraindications:

Renal impairment, myelosuppressed patients, hearing impairment, hypersensitivity to cisplatin or other platinum containing compounds, pregnancy & breastfeeding woman.

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Dosage:

50-120 mg/m2 every 3-4 weeks or 50 mg/m2 on days 1 & 8 every 3-4 weeks or 15-20 mg/m2 on days 1-5 every 3-4 weeks.

Warning and Precautions:

- Prehydration and posthydration therapy, individual counter measures: electrolyte test, hematological test, renal function, neurologic function, hearing function test, liver function. - Prophylactic use of anti-emetic.

Adverse events:

Nephrotoxicity, ototoxicity, myelosuppression, nausea vomiting, neurotoxicity, allergic reactions, serum electrolyte disturbances, hyperuricemia.

Drugs Interaction:

- Nephrotoxic and ototoxic substances - Penicillamine - Bleomycin dan methotrexate - Pyridoxine dan hexamethylamine - Docetaxel - Live vaccine

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