Oleh Admin Kalbe Medical pada November 26, 2018 07:30

Probiotik sebagai Terapi Infeksi Rotavirus pada Bayi

Diare tergolong penyebab mayor mortalitas pada negara-negara berkembang, terutama pada bayi karena adanya berbagai faktor penyebab termasuk infeksi berbagai mikroorganisme. Infeksi rotavirus berakibat lebih fatal pada bayi daripada dewasa. Walaupun saat ini sudah berkembang berbagai jenis vaksin rotavirus, masih ada beberapa kasus diare bayi dan anak kurang dari 5 tahun yang tidak dapat dicegah dengan vaksin tersebut. Selain itu, vaksin ini tergolong vaksin dengan biaya yang cukup mahal sehingga tidak semua golongan masyarakat dapat membelinya. Adapun beberapa studi yang sudah mengidentifikasi efek beberapa strain probiotik (seperti Bifidobacterium, Enterococcus, Lactobacillus, Lactococcus, Propionibacterium, Saccharomyces, dan Streptococcus) untuk infeksi usus; di mana Bifidobacterium dan Lactobacillus merupakan organisme probiotik yang paling banyak memberikan keuntungan.

Park MS, et al, melakukan studi acak, tersamar ganda, dan terkontrol plasebo, pada 57 pasien bayi usia 9-16 bulan yang mengalami infeksi rotavirus yang dibagi ke dalam 2 kelompok, yakni kelompok 1 (28 bayi) diberikan kombinasi probiotik B Longum BORI 2x10^10 CFU/g dan L acidophilus AD031 2x10^9 CFU/g sebanyak 2x sehari; kelompok 2 (29 bayi) diberikan plasebo. Intervensi ini dilakukan selama 3 hari. Kemudian difollow-up perubahan durasi diare dan gejala lainnya seperti muntah dan demam.

Didapatkan hasil bahwa pemberian kombinasi probiotik B Longum BORI 2x10^10 CFU/g dan L acidophilus AD031 2x10^9 CFU/g, sebanyak 2x/hari selama 3 hari pada bayi usia 9-16 bulan; secara signifikan memperpendek durasi diare (nilai P=0,001).(LWA)

Referensi:

Park MS, Kwon B, Ku S, Ji GE. The efficacy of Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 probiotic treatment in infants with Rotavirus infection. Nutrients. 2017;9:887.

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