Oleh admin kalbemed pada August 08, 2018 06:00

Suplementasi Vitamin D Pada kehamilan Mencegah Autisme Anak

Vitamin D merupakan bagian dari keluarga besar ligan yang memberikan sinyal melalui reseptor nukleus termasuk testosteron, estrogen, kortikosteron, hormon tiroid, dan vitamin A. Vitamin D merupakan regulator transkripsional untuk sejumlah besar gen. Untuk memulai aksinya, 1,25(OH)2D3 mengikat reseptor vitamin D. Salah satu jalur kerja kerja vitamin D diketahui berperan penting dalam perkembangan otak. Namun, bukti bahwa status vitamin D selama kehamilan dapat mempengaruhi perkembangan otak baru diketahui pada 10 tahun terakhir.

Ketiga bentuk vitamin D telah diidentifikasi berada di cairan serebrospinal manusia. Seperti steroid lainnya, metabolit vitamin D tampak dapat menembus sawar darah otak. Enzim sitokrom P450 yang berperan dalam formasi 1,25(OH)2D3 (CYP27B1) dan inaktivasinya menjadi 24,25(OH)2D3 juga ada pada sel otak. CYP27B1 juga dideteksi pada otak janin.

Vitamin D dapat mempengaruhi perkembangan otak melalui banyak fungsi endokrin yang telah diketahui seperti regulasi kalsium ekstraseluler, inflamasi terkait sitokin, dan agen yang berpengaruh terhadap stres seperti glukokortikoid. Namun, terdapat banyak aksi yang dimediasi oleh vitamin D secara langsung di otak. Jelas bahwa terdapat banyak mekanisme yang mendasari vitamin D dapat mempengaruhi viabilitas, integritas, konektivitas, dan fungsi baik pada sel neuronal atau non-neuronal pada otak yang sedang berkembang.

Pada wanita hamil, janin mengandalkan cadangan vitamin D ibu secara penuh.Kadar vitamin D yang rendah saat kelahiran atau selama periode postnatal telah berimplikasi secara tidak langsung terhadap kelainan perkembangan otak. Seperti skizofrenia, etiologi kelainan spektrum autistik (ASD) masih belum jelas diketahui. Namun, faktor kehidupan dini juga dipercaya merupakan faktor penting pada kelainan ini. Kadar vitamin D saat hamil yang rendah diperkirakan merupakan faktor risiko untuk ASD.

Infeksi dan/atau inflamasi saat kehamilan merupakan faktor risiko lingkungan untuk kelainan perkembangan otak, termasuk ASD. Aktivasi imunitas maternal pada hewan coba menunjukkan berbagai fenotipe dari perilaku pada neonatus yang relevan dengan autisme. Salah satu penelitian menyimpulkan bahwa suplementasi diet dengan vitamin D kemungkinan dapat mencegah kelainan perkembangan neurologi yang disebabkan oleh inflamasi maternal selama kehamilan.

Penelitian lain menunjukkan bahwa defisiensi viatamin D berkaitan dengan nilai Social responsiveness scale (SRS) yang lebih tinggi (semakin tinggi nilai SRS, maka gangguan sosial juga lebih buruk). Penelitian ini menunjukkan bahwa balita yang terpapar vitamin D rendah secara persisten sejak tengah masa kehamilan hingga kelahiran memiliki risiko terjadinya autisme. Defisiensi 25OHD yang diamati saat tengah masa kehamilan ataupun saat kelahiran berkaitan dengan terjadinya sifat autisme pada anak usia 6 tahun. Diduga bahwa suplementasi vitamin D pada kelompok risiko tinggi dapat mengurangi prevalensi dari faktor risiko ini.


Image: Ilustrasi
Referensi:
1. Eyles D, Burne T, Mcgrath J. Vitamin D in fetal brain development. Semin Cell Dev Biol, 2011; 22: 629-36.
2. Vuillermot S, Luan W, Meyer U, Eyles D. Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. Mol Autism, 2017; 8:9.
3. Vinkhuyzen AAE, Eyles DW, Burne THJ, Blanken LME, Kruithof CJ, Verhulst F. Gestational vitamin D deficiency and autism-related traits: the generation r study. Mol. Psychiatry, 2016.

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