Oleh admin kalbemed pada August 10, 2018 06:00

Manfaat Probiotik pada Penanganan Jaundice pada Anak Baru Lahir

Jaundice pada usia neonatus merupakan salah satu kondisi umum yang membutuhkan penanganan medis dan mengenai 2,4-15% dari bayi baru lahir dalam usia 2 minggu kehidupannya. Sekitar 60% dari bayi cukup bulan dan 80% bayi kurang bulan berkembang menjadi jaundice pada minggu pertama kehidupannya dan sekitar 10% bayi yang mendapatkan ASI tetap mengalami jaundice pada usia 1 bulan.
Efek probiotik pada terapi jaundice neonatus adalah area baru untuk peneliti dan klinisi. Pada klinis, selain fototerapi, obat-obatan, massgae therapy, akunpuntur, atau bahkan tranfusi tukar, suplementasi probiotik dalam ikut serta dalam membantu terapi jaundice neonatal melalui peningkatan imunitas yang utama dilakukan dengan meregulasi koloni bakteri.

Saat ini probiotik menarik perhatian yang sangat besar, mereka didefinisikan sebagai mikroorganisme yang hidup yang dapat memberikan keuntungan terhadap kesehatan untuk host jika dikonsumsi dalam jumlah yang adekuat. Probiotik yang paling sering digunakan adalah bakteri lactic acid dan ragi non-patogenik. Telah ditunjukkan bahwa probiotik dapat digunakan untuk meregulasi gangguan pada gastrointestinal seperti diare, neonatal necrotizing enterocolitis, eradikasi H.pylori.

Saat ini probiotik dan metabolitnya telah banyak diteliti untuk efek kesehatannya pada imunomodulatori, Diabetes tipe 2, hipertensi, dan saat ini untuk jaundice pada neonatus. Beberapa tahun terakhir, probiotik telah digunakan untuk terapi jaundice. Suatu penelitian menyebutkan, spesies Bifidobacterium diduga dapat menlindungi bayi dari jaundice yang disebabkan air susu dan probiotik juga dapat melindungi dari hiperbilirubinemia dengan mempengaruhi motilitas intestinal dan flora usus.

Studi lain, juga menunjukkan bahwa Saccharomyces boulardii memiliki efek dalam mencegah translokasi bakteri dan memperbaiki fungsi pertahanan usus dalam jaundice obstruktif pada hewan percobaan. Probiotik menunjukkan efek pada jaundice obstruktif melalui modulasi fungsi pertahanan usus.
Sebuah studi meta analisis yang meliputi 13 uji klinik dan 1067 neonatus yang mengalami jaundice. Suplementasi probiotik menunjukkan efikasi pada jaundice neonatus. Probiotik menurunkan total serum bilirubin setelah 3, 5 dan 7 hari, tapi juga menurunkan waktu jaundice, dan juga menurunkan lama waktu fototerapi, serta waktu rawat inap saat dibandingkan dengan kelompok kontrol.

Dari beberapa studi tersebut ditemukan bahwa suplementasi probiotik menggunakan Bifidobacterium, S. boulardii, C.butyricum, dan polioligosakarida probiotik yang digunakan secara rutin dalam terapi pelengkap ikut meningkatkan angka efikasi pada terapi jaundice neonatus.

Dari studi-studi di atas menunjukkan bahwa penggunaan probiotik semakin diperluas. Dan di masa depan hal ini dapat menjadi suatu pertimbangan dalam tatalaksana jaundice yang relatif aman. Namun studi lebih baik, dan perlu juga dipahami, saat ini probiotik mulai mengarah setiap indikasi memiliki strain khusus, sehingga perlu dipelajari apakah terkait jaundice membutuhkan strain tertentu. [OEP]


Image: Ilustrasi
Referensi:
1. Chen Z, Zhang LL, Zeng LA, Yang XY, Jiang LC, Gui G, et al. Probiotics Supplementation Therapy for Pathological Neonatal Jaundice: A Systematic Review and Meta-Analysis. 2017 doi: 10.3389/fphar.2017.00432.
2. Bin LW, Jun LH, Sen WT, Qing TX. Therapeutic effects of probiotics on nenonatal jaundice.  2015 doi: 10.12669/pjms.315.7921.
3. Bilgin BS, Koroglu OA, Yalaz M, Karaman S, Kultursay N. Factors Affecting Bilirubin Levels during First 48 Hours of Life in Healthy Infants. 2013 doi: 10.1155/2013/316430.

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Comments

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## linda tovar
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## phoebe guo
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## Erik Wayne
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## leilei1 leilei1
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