Oleh admin kalbemed pada July 05, 2018 06:00

Risedronate Menurunkan Faktor Risiko Penyakit Jantung Koroner

Hasil suatu studi telah menunjukkan bahwa risedronate dapat menurunkan kadar ferritin serum. Peningkatan kadar ferritin telah dikaitkan dengan faktor risiko penyakit jantung koroner pada studi di Finlandia dan Italia. Meskipun ferritin telah dipertimbangkan sebagai penghubung antara percepatan kehilangan tulang dengan aterosklerosis, namun dampak jangka panjang agen terapeutik yang secara luas digunakan untuk terapi osteoporosis, seperti bisphosphonate, pada kadar ferritin belum pernah diteliti sebelumnya. Namun saat ini telah dilakukan studi untuk menilai efek risedronate pada kadar ferritin serum pada wanita pascamenopause dengan osteoporosis.

Pada studi label terbuka, prospektif, dan tanpa pembanding, 68 wanita pascamenopause dengan osteoporosis mendapat risedronate oral 35 mg/minggu selama 6 bulan terapi. Pemeriksaan sampel darah untuk profil lemak, HbA1c, insulin, fibrinogen, C-reactive protein, osteoprotegerin, dan ferritin dilakukan saat basal dan setelah 6 bulan terapi. Pulse-wave velocity dan augmentation index saat basal ditentukan menggunakan SphygmoCor versi 7.1.

Hasilnya menunjukkan bahwa ferritin serum rata-rata menurun secara bermakna dari 62,1 menjadi 46,7 mcg/dL selama periode terapi. Pada analisis regresi linier multipel, prediktor serum ferritin adalah pulse-wave velocity, C-reactive protein, insulin, dan kolesterol HDL lebih baik dibandingkan dengan  awal penelitian.

Dari hasil studi disimpulkan bahwa terapi risedronate dikaitkan dengan penurunan kadar ferritin serum secara bermakna pada wanita pascamenopause dengan osteoporosis dan faktor risiko kardiovaskuler.[EKM]


Image: Ilustrasi
Referensi:
1. Feldbrin Z, Luckish A, Shargorodsky M. Effects of long-term risedronate treatment on serum ferritin levels in postmenopausal women with osteoporosis: The impact of cardiovascular risk factor load. Menopause. 2016 Jan;23(1):55-9. doi: 10.1097/GME.0000000000000480.
2. Williams MJ, Poulton R, Williams S. Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. Atherosclerosis. 2002 Nov;165(1):179-84.

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