Oleh admin kalbemed pada July 03, 2018 06:00

Vitamin C Mempunyai Efek Sinergis dengan Obat Antituberkulosis

Hepatotoksisitas yang disebabkan oleh obat tuberkulosis, rifampin dan isoniazid, merupakan masalah utama pada pasien tuberkulosis. Vitamin C dan N-acetyl cysteine (NAC) merupakan antioksidan yang dapat mengurangi hepatotoksisitas.

Suatu studi telah dilakukan untuk meneliti efek vitamin C dan NAC secara individual pada aktivitas antibakteri obat antituberkulosis melawan Mycobacterium tuberculosis dan Staphylococcus aureus. Dalam studi tersebut, ditentukan MIC [minimum inhibitory concentration]  setiap senyawa terhadap semua strain bakteri tersebut. Rifampin diuji dalam konsentrasi dua kali lipat serial sendiri atau dalam kombinasi dengan NAC atau vitamin C.

Hasilnya menunjukkan bahwa MIC rifampin terhadap strain S.aureus adalah 0,008-0,032 mcg/mL. MIC rifampin dan isoniazid terhadap strain M. tuberculosis masing-masing 40 dan 0,2 mcg/mL. MIC rifampin menurun dua kali lipat dengan kombinasi vitamin C untuk semua strain S.aureus, sedangkan NAC tidak mempengaruhi aktivitas antibakteri rifampin. Vitamin C dan NAC mempunyai efek yang nyata pada aktivitas antibakteri obat antituberkulosis terhadap M.tuberculosis.

Disimpulkan bahwa terdapat efek sinergistik antara rifampin atau isoniazid dengan vitamin C terhadap semua strain yang diuji, namun, terapi kombinasi rifampin dan isoniazid dengan NAC tidak efektif. Hasil studi ini menunjukkan manfaat kombinasi obat antituberkulosis dengan vitamin C untuk mengeradikasi infeksi mikroba. [EKM]


Image: Ilustrasi
Referensi:
1. Khameneh B, Fazly Bazzaz BS, Amani A, Rostami J, Vahdati-Mashhadian N. Combination of anti-tuberculosis drugs with vitamin C or NAC against different Staphylococcus aureus and Mycobacterium tuberculosis strains. Microb Pathog. 2016;93:83-7. doi: 10.1016/j.micpath.2015.11.006.
2. Vahdati-Mashhadian N, Jafari MR, Sharghi N, Sanati T. Protective effects of vitamin C and NAC on the toxicity of Rifampin on Hepg2 cells, Iran. J. Pharm. Res. 2013;12(1):141e146.

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Comments

Erik Wayne
## Erik Wayne
Monday, July 09, 2018 10:16 AM
Terima kasih sudah berbagi pos! instagram technology Alasan lain untuk makan lebih banyak buah dengan vitamin C
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## phoebe guo
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