Oleh Admin Kalbe Medical pada May 31, 2018 06:30

Curcuma longa Mempunyai Efek Antivirus Dengue

Dengue merupakan penyakit infeksi yang sering ditemukan, yang disebabkan oleh virus dengue dan merupakan penyakit endemik di daerah tropis dan subtropik. Di Indonesia, Bali dan DKI Jakarta mempunyai jumlah kasus DHF paling tinggi di 2013, hingga 168,5/100.000 populasi. Sebagai tambahan, dengue menjadi masalah kesehatan utama di Indonesia, dan menjadi penyebab utama perawatan di rumah sakit dan kematian pada anak. Virus dengue (DENV) merupakan virus family Flaviviridae dengan 4 serotipe (DENV-1, DENV-2, DENV-3, dan DENV-4) yang dibedakan oleh sifat genetik dan antigenik.

Manifestasi klinik dari infeksi DENV berkisar dari asimptomatik, Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF), hingga Dengue Shock Syndrome (DSS). DHF bisa berkembang menjadi DSS pada kasus syok akibat kebocoran plasma dan dapat menjadi fatal. Telah diketahui bahwa jumlah virus terkait dengan keparahan penyakit, dan penurunan viremia pada pasien terinfeksi diharapkan akan mencegah perkembangan manifestasi menjadi DHF/DSS. Terapi DENV saat ini hanya dengan mempertahankan cairan tubuh pasien, karena hal ini penting dalam penatalaksanaan DENV berat. Di Asia, ekstrak Curcuma longa (C. domestica Val.) atau kunyit dengan curcumin sebagai senyawa aktif utamanya mempunyai efek antioksidan, antiinflamasi, antivirus, antimikroba, dll. Diharapkan bahwa ekstrak C. longa juga mempunyai efek antivirus pada replikasi DENV.

Suatu studi telah dilakukan untuk menentukan efek antivirus dari ekstrak C. longa terhadap virus dengue in vitro dan in vivo, serta efek toksisitasnya pada hati dan ginjal mencit ddY. Aktivitas antivirus (IC50) dan toksisitas (CC50) in vitro diperiksa pada sel Huh7it-1 masing-masing dengan focus assay dan MTT assay. Untuk menentukan indeks selektivitas (SI), digunakan nilai CC50 dan IC50. Dosis aman yang diperoleh digunakan untuk uji toksisitas hati dan ginjal dengan penemuan histopatologi dan biokimia. Ekstrak C. longa diberikan secara oral dengan dosis 0,147 mg/m untuk setiap mencit 2 jam setelah diinjeksi dengan sel Huh7it-1 yang terinfeksi virus dengue (DENV-2). Serum diambil dari intraorbital 6 jam dan 24 jam setelah infeksi dan focus assay digunakan untuk menentukan jumlah virus.

Dalam studi ini, hasilnya menunjukkan bahwa nilai IC50 17,91 mcg/mL, sedangkan nilai CC50 85,4 mcg/mL. Nilai SI dari C. longa 4,8. In vivo, ditemukan bahwa C. longa secara nyata menurunkan jumlah virus setelah 24 jam. Pemeriksaan histopatologi tidak menunjukkan adanya kelainan spesifik pada hati dan ginjal. Tidak ada peningkatan bermakna pada kadar SGPT, SGOT, urea, dan creatinine. Dapat disimpulkan bahwa C. longa dapat berpotensi digunakan sebagai antivirus dengue (DENV) dengan sitotoksisitas yang rendah dan penghambatan yang efektif. (EKM)

Image : Ilustrasi
Referensi:
1.Ichsyani M, Ridhanya A, Risanti M, Desti H, Ceria R, Putri DH, et al. Antiviral effects of Curcuma longa L. against dengue virus in vitro and in vivo. Earth Environ Sci. 2017;101:012005 doi:10.1088/1755-1315/101/1/ 012005
2.Araújo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz. 2001;96(5):723-8.

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## chan yuan
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## chenlina chenlina
Friday, August 10, 2018 2:22 PM
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