Oleh admin kalbemed pada April 05, 2018 06:00

Efek Perlindungan SOD [Superoxide dismutase] Terhadap Motilitas Sperma

Superoxide dismutase (SOD) merupakan suatu antioksidan enzimatik yang sangat penting di dalam tubuh.  SOD in akan menetralkan  metabolit yang toksik dari oksigen (radikal bebas) superokside anion (O2-) yang merupakan mediator  penting dalam kerusakan jaringan.  Peorksidasi dari asam lemak tak jenuh pada fosfolipid membran sel  dapat disebabkan oleh adanya radikal bebas, dan   terjadinya peroksidasi lemak ini akanmenyebabkan  hilangnya viabilitas sel dan berakhir  dengankematian sel atau dalam skala yang luas menjadi nekrosis jaringan.

Radikal bebas (al. superokside) tidak hanya toksik terhadap sel-sel jaringan saja, namun dari studi yang ada, radikal bebas juga toksik terhadap  sperma yang ditunjukkan dengan hilangnya motilitas sperma akibat adanya peroksidasi lemak akibat radikal bebas.  Untuk menjaga kualitas sperma, maka secara alamiah kadar  SOD di dalam testis tinggi, yaitu sekitar  2,16 ug/ mg (CuZnSOD)  nomor tiga setelah jaringan hati (4,71 ug/mg) dan  jaringan otak (3,7 ug/ mg).

Dalam sebuah studi yang melibatkan sebanyak 130 responden yang  melalukan massturbasi sehingga mendapatkan 130 sampel sperma dan selanjutnya dilakukan pemeriksaan kadar SOD dan lipid peroksidasinya.  Dari studi tersebut menujukkan bahwa, terdapat hubungan  yang bermakna antara aktivitas SOD dalam sperma   dengan jumlah  sperma yang motil. Dan sebaliknya  terdapat hubungan yang bermakna antara  kadar MDA (Malondialdehide – produk peroksidasi lemak) dengan jumlah sperma yang tidak motil.

Dari studi tersebut menunjukkanbahwa SOD yang terdapat di dalam cairan semen akan melindungi sperma terhadap kerusakan akibat perosidasi lemak, yang ditandai dengan berkurangnya motilitas dari sperma.[Red]



Image: Ilustrasi
Referensi:
1. Kobayashi T, Miyazaki T, Natori M. Protective role os superoxide dismutase in human sperm motifity: superoxide dismutase  activity and lipid peroxide in human seminal plasma and spermatozoa. Hum Reprod. 1991 Aug;6(7):987-91.
2. Halliwel B. et al. Free  Radicals in Biology and Medicine, 3th edition. Oxford University Press. 1999.

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