Oleh Admin Kalbe Medical pada November 30, 2017 07:30

Kondisi Anemia dapat Mempercepat Stadium Akhir Pasien Penyakit Ginjal Kronik

Anemia merupakan salah satu manifestasi yang dialami pasien penyakit ginjal kronik (PGK). Pasien PGK yang mengalami anemia dikatakan memiliki korelasi dengan peningkatan risiko penyakit ginjal tahap akhir (PGK terminal). Pernyataan ini disampaikan dalam pertemuan American Society of Nephrology's Kidney Week 2017 yang didasarkan pada penelitian yang dilakukan terhadap 3919 pasien dengan PGK, di mana 1859 (47,4%) pasien tersebut mengalami anemia.  

Berdasarkan kriteria WHO, kategori anemia adalah apabila kadar hemoglobin kurang dari 12 g/dL pada wanita dan kurang dari 13 g/dL pada pria. Populasi subjek dalam penelitian ini memiliki usia rata-rata 58 tahun, dan 45% pasien adalah perempuan. Fungsi ginjal dinilai dengan rata-rata estimasi laju filtrasi glomerulus (eLFG) adalah 45 mL/min/1,73 m2 dan nilai median proteinuria adalah 0,19 g per 24 jam. Dibandingkan dengan pasien yang tidak mengidap anemia, pasien dengan anemia memiliki usia yang lebih tua dan lebih banyak dari kulit hitam atau Hispanik. Mereka juga cenderung memiliki nilai eGFR dan nilai proteinuria yang lebih rendah.

Selama follow-up rata-rata selama 7,8 tahun, penyakit ginjal tahap akhir dialami pada 1010 pasien dan 994 pasien tersebut meninggal. Pada subjek penelitian yang kondisinya telah disesuaikan, pasien dengan anemia memiliki risiko jatuh ke dalam penyakit ginjal tahap akhir 31% lebih besar dibandingkan dengan pasien yang tidak menderita anemia. Setiap penurunan 1 gram dalam hemoglobin berhubungan dengan peningkatan risiko penyakit ginjal tahap akhir secara signifikan sebesar 10%. Anemia ini sendiri tidak secara signifikan berkorelasi dengan angka mortalitas.

Hasil penelitian ini membuktikan pentingnya penatalaksanan anemia yang baik pada pasien penyakit ginjal tahap akhir, sehingga dapat memperlambat progresivitas penyakit yang akan membuat pasien menjadi lebih lama untuk jatuh ke dalam penyakit ginjal tahap akhir. (DHS)

Image : Ilustrasi
Referensi:
1.Saraf S, Ricardo AC, Lash JP, et al. Anemia is a risk factor for incident ESRD. Presented in poster format at Kidney Week 2017 in New Orleans (Oct. 31-Nov. 5). Poster FR-PO391.
2.Charnow JA. Anemia raises ESRD risk in patients with chronic kidney disease. [Internet]. [cited 2017 November 21]. Available from:  http://www.renalandurologynews.com/kidney-week-2017/chronic-kidney-disease-patients-anemia-raises-esrd-risk/article/703952/

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