Oleh Admin Kalbe Medical pada November 28, 2017 07:30

Defisiensi Vitamin D Berkaitan dengan Penyakit Vitiligo, Benarkah?

Vitiligo merupakan suatu kondisi yang ditandai dengan bercak depigmentasi (hilangnya pigmentasi) pada kulit. Depigmentasi disebabkan oleh kematian sel epitel yang disebut dengan melanosit, yaitu sel dalam kulit yang memproduksi pigmen kulit yang disebut dengan melanin, yang memberi warna pada kulit dan terlibat dalam proteksi melawan paparan sinar UV. Meskipun vitiligo bukanlah kondisi yang fatal, namun vitiligo dikaitkan dengan peningkatan risiko terhadap sunburn (luka bakar akibat paparan sinar matahari), kanker kulit, tekanan sosial, kehilangan pendengaran, dan inflamasi.

Sementara penyebab vitiligo belum diketahui secara umum, namun telah dikaitkan dengan kondisi autoimun, auto-inflamasi, dan genetik. Sebagai tambahan, terdapat beberapa penelitian yang mengaitkan vitiligo dengan status vitamin D, meskipun penelitian ini masih dalam tahap awal. Karena adanya hipotesis bahwa vitiligo merupakan hasil dari disfungsi imun, maka para peneliti meneliti peranan status vitamin D terhadap aktivitas penyakit pada individu dengan vitiligo. Para peneliti melibatkan total 70 individu di mana 30 individu didiagnosis vitiligo, dan 40 individu lainnya tanpa vitiligo sebagai kontrol. Semua peserta penelitian diwawancara untuk menentukan riwayat medis, paparan sinar matahari, dan pola makan.

Untuk pasien vitiligo, aktivitas penyakit ditentukan dengan menilai perubahan kelainan kulit lama atau penampakan kelainan kulit yang baru dalam 3 bulan terakhir. Selain itu, juga dilakukan pengukuran vitamin D dan kadar sitokin proinflamasi interleukin-17 (IL-17), suatu petanda aktivitas penyakit vitiligo yang umum. Penelitian ini menemukan bahwa kadar vitamin D rata-rata pada pasien vitiligo secara bermakna lebih rendah dibanding kelompok kontrol, pada pasien vitiligo mempunyai kadar IL-17 serum yang secara bermakna lebih tinggi dibanding kontrol, dan tidak terdapat kaitan bermakna antara IL-17 dan kadar vitamin D.

Dari hasil penelitian tersebut, para peneliti menyimpulkan bahwa vitamin D menunjukkan peranan potensial dalam patogenesis atau terjadinya vitiligo yang kompleks. Namun, penelitian ini terbatas dengan jumlah peserta penelitian yang sedikit dengan desain cross-sectional. Penelitian lebih lanjut diperlukan untuk menentukan patologi status vitamin D pada pasien vitiligo. (EKM)

Image : Ilustrasi
Referensi:
1.Peterson R. Vitamin D deficiency may be associated with the pathogenesis of vitiligo, according to recent study [Internet]. 2017 [cited 2017 nov 27] Available from: https://www.vitamindcouncil.org/vitamin-d-deficiency-may-be-associated-with-the-pathogenesis-of-vitiligo-according-to-recent-study/
2.Aly D, Mohammed F, Sayed K, Gawdat H, Mashaly H, Abdel Hay R, et al. Is there relation between vitamin D and interleukin-17 in vitiligo? A cross-sectional study. Dermatology. 2017. doi: 10.1159/000479925.

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