Oleh Admin Kalbe Medical pada November 23, 2017 07:30

Pengobatan dengan Hydroxychloroquine pada Pasien Lupus Bermanfaat Menurunkan Kadar LDL

Systemic lupus erythematosus (SLE) atau dikenal juga dengan penyakit lupus adalah penyakit autoimun sistemik kronik dengan manifestasi pada kulit, sendi, ginjal, darah, dan sistem saraf. Patogenesis SLE belum dipahami sepenuhnya tetapi berkaitan dengan reaksi autoimun terhadap inti sel dan DNA dengan dibentuknya anti-nuclear antibody dan anti-dsDNA antibody. Karena mekanisme terjadinya penyakit lupus utamanya adalah melalui proses autoimun, maka dapat digunakan beberapa obat-obatan imunosupresif sebagai untuk mengobati penyakit ini. Beberapa contoh obat-obatan imunosupresif yang digunakan pada penyakit lupus adalah methotrexate, azathioprine, mycophenolate acid, dan hydroxychloroquine.

Hydroxychloroquine adalah obat yang awalnya digunakan sebagai profilaksis malaria. Akan tetapi, kemudian diketahui bahwa hydroxychloroquine juga memiliki efek imunosupresif yang bermanfaat apabila digunakan sebagai pengobatan penyakit autoimun seperti penyakit lupus. Tidak hanya itu, akhir-akhir ini diketahui bahwa pasien dengan penyakit lupus yang menggunakan pengobatan hydroxychloroquine ternyata mengalami perbaikan profil lipidnya, terutama berupa penurunan kadar LDL.

Hal ini diketahui melalui sebuah penelitian yang dilakukan oleh dr. Babary dan tim dari USA. Penelitian ini dilakukan dengan metode meta-analisis dari 8 penelitian sebelumnya dengan total 559 pasien. Setelah digabungkan data dari 8 penelitian ini, diketahui pengobatan hydroxychloroquine bermanfaat menurunkan kadar LDL plasma sebesar 24,397 mg/dL.

Kesimpulan:
Dari penelitian ini didapatkan bahwa pengobatan menggunakan hydroxychloroquine pada pasien lupus memiliki manfaat tambahan memperbaiki profil lipid, lebih spesifiknya menurunkan kadar LDL. (NNO)

Image : Ilustrasi
Referensi:
1.Systemic lupus erythematosus (SLE): Practice essentials, background, pathophysiology [Internet]. 2017 Nov 14 [cited 2017 Nov 15]; Available from: https://emedicine.medscape.com/article/332244-overview?pa=kLQc4QPaMqMkzWSSsz6Y08rJDUG5PQ8%2Fm34OdPgNO11t4jo8Bct%2FIaw4EmuHkaDHpr9Q5QQWBKImvKFpQyobzC8HoCpv88EfsR0xVZ6JHe4%3D
2.Babary H, Liu X, Ayatollahi Y, Chen XP, Doo L, Uppaluru LK, et al. Favorable effects of hydroxychloroquine on serum low density lipid in patients with systemic lupus erythematosus: A systematic review and meta-analysis. Int J Rheum Dis. 2017 Sep 8;

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