Oleh Admin Kalbe Medical pada November 07, 2017 07:30

Konsumsi Kopi Dikaitkan dengan Kekakuan Hati yang Lebih Rendah pada Pasien Perlemakan Hati dan Hepatitis

Kopi adalah minuman kedua tersering yang paling populer di dunia setelah air putih dan telah dikonsumsi selama berabad-abad sebelumnya. Kopi telah diduga memiliki manfaat bagi kesehatan. Beberapa bukti terbatas menyebutkan bahwa kopi menurunkan beberapa risiko kanker, penyakit kardiovaskular, hipertensi, dan neurodegeneratif (Parkinson dan Alzhiemer). Selain itu, kopi juga disebutkan menurunkan risiko dari perkembangan diabetes tipe 2, sindrom metabolik, dan mencegah diabetes gestasional.

Studi sebelum ini menyebutkan bahwa konsumsi hati dikaitkan dengan penurunan risiko kanker hati, lebih tepatnya karsinoma hepatoseluler. Saat ini terdapat bukti yang muncul bahwa kopi memiliki efek hepatoprotektor dalam berbagai kondisi kelainan hati, mulai dari peningkatan enzim hati, fibrosis hati, dan karsinoma hepatoseluler. Pada populasi sehat juga ditemukan risiko penyakit yang lebih rendah serta nilai AST/ALT Gamma-GT yang lebih rendah pada orang yang mengonsumsi kopi secara rutin. Dengan berkembangnya teknologi transient elastography dengan fibroscan yang diketahui cukup akurat dan sensitif dapat menjadi metode non-invasif untuk mengetahui fibrosis hati dan perlemakan hati. Pada studi yang mengukur hubungan kekakuan hati dan konsumsi kopi diperiksa melalui fibroscan.

Pada sebuah studi, total 1018 pasien (155 pasien NAFLD, 378 HCV, 485 HBV) dengan data diteliti. Pasien ini diteliti menurut jumlah konsumsi kopinya dalam 1 hari. Studi ini menemukan bahwa intake kopi 2/lebih cangkir dalam sehari berhubungan dengan kekakuan hati yang lebih rendah. Di studi lain dengan 2424 subjek, hubungan antara konsumsi kopi dan penurunan kekakuan hati dikonfirmasi dengan regresi multi variabel (ORmod0,75, 95% CI 0,33-1,67; ORfreq 0,39, 95% CI 0,18-0,86; p=0,005). Studi ini juga mengemukakan konsumsi teh menurunkan kekakuan hati, namun tidak dijelaskan subtipe teh apa yang dapat menurunkan kekakuan hati.

Pada kesimpulannya, berdasarkan 2 studi ini dapat ditemukan bahwa konsumsi kopi dapat menurunkan kejadian kekakuan hati pada populasi umum ataupun pasien dengan gangguan hati. (OEP)

Image : Ilustrasi
Referensi:
1.Hodge A, Lim S, Goh E, Wong O, Marsh P, Knight V, et al. Coffee intake is associated with lower liver stiffness in patients with non-alcoholic fatty liver disease, hepatitis c, and hepatitis b. Nutrients. 2017;9(56):1-9.
2.Alferink LJM, Fittipaldi J, Keifte-de Jong JC, Taimr P, Hansen BE, Metseelar HJ, et al. Coffee and herbal tea consumption is associated with lower liver stiffness in the general population: The Rotterdam study. J Hepatol. 2017;67(2):339-48.

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