Oleh Admin Kalbe Medical pada November 03, 2017 07:30

House Dust Mite Immunotherapy Efektif untuk Memperbaiki Gejala Rinitis Alergi

Rinitis alergi adalah salah satu penyakit alergi yang dapat terjadi pada dewasa dan anak. Penyakit ini ditandai oleh episode berulang dari hidung tersumbat, bersin-bersin, hidung berair dan gatal. Meskipun penyakit ini tidak bersifat fatal, tetapi penyakit ini dapat berakibat penurunan kualitas hidup pada dewasa dan anak. Pengobatan menggunakan oral antihistamin telah terbukti efektif. Akan tetapi, pengobatan ini seringkali mengakibatkan efek samping berupa rasa kantuk. Sebagai alternatifnya bisa menggunakan pengobatan kortikosteroid intranasal. Kortikosteroid intranasal relatif efektif, namun dalam jangka panjang dapat berakibat pada efek samping atrofi konka.

Salah satu penyebab dari gejala rinitis alergi adalah adanya alergi terhadap tungau debu rumah/house dust mite. Diperlukan penghindaran terhadap alergen, misalnya dengan membersihkan rumah secara rutin untuk mencegah berkembangbiaknya tungau debu rumah. Selain itu, ada juga pengobatan yang dapat mengurangi alergi terhadap tungau debu rumah. Pengobatan ini dikenal sebagai house dust mite immunotherapy.

Dr. Guo dan tim dari Cina melakukan sebuah uji klinik untuk mengevaluasi efektivitas dan keamanan house dust mite immunotherapy untuk meredakan gejala rinitis alergi. Uji klinik ini diterbitkan di Amerivan Journal of Rhinology and Allergy bulan Juli tahun 2017. Pada uji klinik ini, sebanyak 48 pasien rinitis alergi yang mendapatkan pengobatan standar diacak untuk mendapatkan house dust mite immunotherapy menggunakan metode SLIT atau plasebo selama 1 tahun.  

Hasil yang didapatkan adalah pada kelompok house dust mite immunotherapy mengalami perbaikan gejala serta penurunan kebutuhan pengobatan untuk rinitis alergi (keduanya p<0,05). Dari studi ini dapat disimpulkan bahwa pada pasien rinitis alergi, pengobatan menggunakan house dust mite immunotherapy dapat bermanfaat meredakan gejala rinitis alergi dan menurunkan kebutuhan pengobatan secara bermakna. (NNO)

Image : Ilustrasi
Referensi:
1.Min YG. The pathophysiology, diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res. 2010;2(2):65–76.
2.Guo Y, Li Y, Wang D, Liu Q, Liu Z, Hu L. A randomized, double-blind, placebo controlled trial of sublingual immunotherapy with house-dust mite extract for allergic rhinitis. Am J Rhinol Allergy 2017;31(4):42–7.

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Max Taranov
## Max Taranov
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Max Taranov
## Max Taranov
Thursday, September 20, 2018 11:53 PM
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