Oleh Admin Kalbe Medical pada November 02, 2017 07:30

Pemberian Kombinasi DHA, Vitamin D3, dan Uridine dapat Memperbaiki Fungsi Kognitif pada Anak

Belajar dan memori membutuhkan perubahan struktural pada neuron serta hubungan neuronal dalam bentuk up-down regulasi reseptor, membran channels, neurotransmiter, dan hubungan sinaptik. Perbedaan diet berpengaruh terhadap fungsi otak pada hewan dan manusia. Asupan makanan yang paling berperan dalam sintesis membran fosfolipid adalah uridin dan DHA, yang pada penelitian preklinis menunjukkan peningkatan jumlah sinaps baru dan meningkatkan kemampuan belajar serta memori. Suplementasi DHA juga meningkatkan produksi brain-derived neurotrophic factor (BDNF), sebagai mediator neurogenesis pada hipokampus dan penting untuk memori. Dari sistematik review, juga disebutkan bahwa vitamin D yang rendah berhubungan dengan penurunan fungsi kognitif dan meningkatkan kejadian demensia.

Sampai saat ini belum ada penelitian yang menilai efek kombinasi antara DHA, uridin, dan vitamin D3 terhadap fungsi kognitif anak. Oleh karena itu, dilakukan penelitian dengan tujuan untuk menilai efek kombinasi DHA, vitamin D3, dan uridin terhadap fungsi motorik dan kognitif anak. Desain dan metode penelitiannya adalah acak, tersamar ganda, dengan plasebo sebagai kontrol. Subjek sebanyak 16 orang anak dengan rentang usia 8-11 tahun yang kemudian diacak menjadi 2 kelompok. Kelompok perlakuan mendapatkan suplementasi DDU (DHA 500 mg, vitamin D3 10 µg, dan uridin 1000 mg) dan kelompok kontrol hanya mendapatkan plasebo. Intervensi dilakukan selama 6 minggu dan selama intervensi subjek dilatih selama 30 menit 3 kali dalam seminggu dengan menggunakan internet-based cognitive and motor training program (Mitii). Sebelum dan setelah intervensi dilakukan pencatatan asupan makan harian, pemeriksaan darah, tes motorik dan kognitif.

Hasilnya menunjukkan bahwa pada kelompok perlakuan terjadi peningkatan konsentrasi vitamin D3 dalam plasma (p=0,023) dan DHA (p<0,001) secara bermakna. Fungsi kognitif juga mengalami perbaikan pada kelompok perlakuan yang dinilai dari hasil tes motorik dan sensorik. Dari hasil penelitian pemberian kombinasi DHA 500 mg, vitamin D3 10 µg, dan uridin 1000 mg selama 6 minggu dapat memperbaiki fungsi kognitif pada anak yang ditandai dengan perbaikan tes motorik dan kognitif serta peningkatan kadar DHA dan vitamin D3 dalam darah. (LAI)

Image : Ilustrasi
Referensi:
1.Hansen SL, Rosenbaum AR, Voigt CB, Hellgren LI, Sorensen ADM, Jacobsen C, et al. Supplementation of docosahexaenoic acid (DHA), vitamin D3 and uridine in combination with six weeks of cognitive and motor training in prepubescent children: a pilot study. BMC Nutrition 2017;3:37.
2.Harms LR, Burne TH, Eyles DW, McGrath JJ. Vitamin D and the brain. Best Pract Res Clin Endocrinol Metab. 2011;25:657–69.
3.Sakamoto T, Cansev M, Wurtman RJ. Oral supplementation with docosahexaenoic acid and uridine-5’-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res. 2007;1182:50–9

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