Oleh Admin Kalbe Medical pada October 05, 2017 07:30

Golimumab Efektif Memperbaiki Gejala dan Tanda Psoriatic Arthritis

Psoriatic arthritis adalah penyakit peradangan autoimun pada sendi yang terjadi pada pasien yang mengalami psoriasis. Sebanyak 30% dari pasien psoriasis diketahui mengalami psoriatic arthritis. Gangguan sendi yang dialami oleh pasien psoriatic arthritis biasanya terjadi pada banyak sendi sekaligus. Kerusakan sendi dapat bersifat progresif dan dapat berujung pada kecacatan. Seperti halnya psoriasis, psoriatic arthritis juga sebenarnya adalah penyakit autoimun sistemik, di mana terjadi peningkatan kadar dari beberapa interleukin, misalnya interleukin-10, interleukin-17, dan interleukin-23. Selain itu, pada psoriasis juga terjadi peningkatan aktivitas dari sel T, terutama sel T CD6.

Beberapa obat-obatan monoclonal antibody yang baru, bekerja dengan cara menghambat kerja interleukin, misalnya ustekinumab bekerja menghambat interleukin 17/23 dan secukinumab menghambat interleukin 10. Golimumab adalah monoclonal antibody yang bekerja dengan cara menhambat TNF-α. Dr. Kavanaugh dan tim dari USA melakukan sebuah uji klinik fase 3, yang mengevaluasi efektivitas dan keamanan golimumab intravena pada pasien psoriatic arthritis. Pada uji klinik ini, pasien psoriatic arthritis diacak untuk mendapatkan pengobatan golimumab 2 mg/kg (n=241) atau plasebo pada minggu ke-0, 4, 12, dan 20. Parameter yang dievaluasi adalah proporsi pasien yang mencapai ACR20 pada minggu ke-14.

Hasilnya didapatkan bahwa pada minggu ke-14, sebanyak 21,8% pasien pada kelompok plasebo mencapai skor ACR20 dan sebanyak 75,1% pasien pada kelompok golimumab mencapai skor ACR20 (p<0,001). Pada minggu ke-24, sebanyak 40,6% pasien di kelompok plasebo dan sebanyak 46,3% pasien pada kelompok golimumab mengalami kejadian tidak diinginkan.

Kesimpulan:
Pada pasien yang mengalami psoriatic arthritis, penggunaan golimumab dapat bermanfaat untuk memperbaiki gejala dan tanda. (NNO)

Image : Ilustrasi
Referensi:
1.Psoriatic arthritis: Practice essentials, background, pathophysiology and etiology [Internet]. 2017 Sep 15 [cited 2017 Sep 30]. Available from: http://emedicine.medscape.com/article/2196539-overview
2.Kavanaugh A, Husni ME, Harrison DD, Kim L, Lo KH, Leu JH, et al. Safety and efficacy of intravenous golimumab in patients with active psoriatic arthritis: Results through week 24 of the GO-VIBRANT study. Arthritis Rheumatol. 2017 Aug 13. doi: 10.1002/art.40226.

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