Oleh Admin Kalbe Medical pada October 03, 2017 07:30

Kaitan Status Vitamin C dengan Fungsi Kognitif

Vitamin C (ascorbate) berperan sebagai agen pereduksi yang mendonorkan elektron pada berbagai reaksi enzimatik dan non-enzimatik. Vitamin C merupakan kofaktor untuk setidaknya 8 reaksi enzimatik yang terlibat dalam proses produksi kolagen, mencegah  mutasi genetik yang berbahaya, melindungi sel darah putih, produksi carnitine, dan vital untuk energi. Vitamin C juga berperan dalam diferensiasi dan maturasi sel saraf, pembentukan mielin, serta modulasi sistem kolinergik, katekolinergik, dan glutaminergik.

Vitamin C mempengaruhi neurotransmisi sinaptik dengan mencegah ikatan neurotransmiter pada reseptor, dengan memodulasi pelepasan dan ambilan kembali neurotransmiter, dan bekerja sebagai kofaktor dalam sintesis neurotransmiter. Peran neuromodulasi lain dari vitamin C adalah keterlibatannya dalam ambilan kembali glutamatepresinaptik, yang menunjukkan efek langsung dalam mencegah overstimulasi sel saraf oleh glutamate.

Suatu kajian sistematik telah menilai kaitan antara status vitamin C dan performa kognitif pada individu dengan kognitif intak ataupun terganggu. Sebanyak 50 studi dengan 5 RCT, 24 studi prospektif, 17 studi cross-sectional, dan 4 studi case-control. Dari studi-studi tersebut, 36 studi dilakukan pada individu sehat dan 14 studi pada individu dengan gangguan kognitif (termasuk Alzheimer dan demensia). Status vitamin C diukur dengan menggunakan kuesioner frekuensi makanan atau vitamin C plasma. Kognisi dinilai menggunakan berbagai tes, kebanyakan Mini-Mental-State-Examination (MMSE).

Hasilnya menunjukkan bahwa kadar vitamin C rata-rata lebih tinggi pada kelompok kognitif intak dibanding kelompok dengan kognitif terganggu. Tidak ada korelasi antara kadar vitamin C dan fungsi kognitif MMSE pada individu dengan gangguan kognitif. Namun, penilaian kualitatif menunjukkan kaitan potensial antara kadar vitamin C plasma dan kognisi. (EKM)

Image : Ilustrasi
Referensi:
1.Travica N, Ried K, Sali A, Scholey A, Hudson I, Pipingas A. Vitamin C status and cognitive function: A systematic review. Nutrients. 2017;9(9). pii: E960. doi: 10.3390/nu9090960.
2.Harrison FE. A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer’s disease. J Alzheimers Dis. 2012;29(4):711–26. doi:  10.3233/JAD-2012-111853

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