Oleh Admin Kalbe Medical pada November 05, 2018 07:30

Vitamin D Berpotensi Membantu Memperbaiki Keparahan Akne

Akne vulgaris merupakan suatu penyakit inflamasi kronik pada kulit yang kompleks dan sering dijumpai. Pengaruh hormonal, sumbatan dan hiperkeratinisasi folikuler, peningkatan sekresi sebum, kolonisasi bakteri Propionibacterium acnes, serta inflamasi terlibat dalam patogenesis akne. P.acnes memicu aktivasi sitokin oleh Toll-like receptor, yang berarti bahwa sistem imun bawaan juga penting untuk terjadinya akne.

Vitamin D telah diketahui berperan sebagai modulator metabolisme kalsium dan homeostasis. Vitamin D dapat mempengaruhi sistem imun bawaan dan adaptif melalui efeknya pada limfosit T dan B, sel dendritik, dan makrofag, serta dikaitkan dengan penyakit inflamasi sistemik. Telah diketahui pula sebelumnya bahwa defisiensi vitamin D dapat berdampak pada berbagai penyakit kulit. Identifikasi reseptor vitamin D pada sebosit manusia dan modulasi lemak serta produksi sitokin oleh vitamin D menunjukkan kaitan yang mungkin antara vitamin D dan akne.

Suatu studi telah dilakukan untuk membandingkan kadar vitamin D serum pada pasien dengan akne nodulokistik dibanding kontrol sehat untuk menentukan adakah kaitan antara vitamin D dan akne. Dalam studi ini, kadar 25(OH)D diukur pada 43 pasien akne nodulokistik dan 46 subjek kontrol sehat. Hasilnya menunjukkan pada pasien dengan akne nodulokistik, kadar 25(OH)D secara bermakna lebih rendah dibanding subjek kontrol sehat (p<0,05). Disimpulkan bahwa terdapat hubungan antara kadar vitamin D yang rendah dan akne.

Studi selanjutnya dilakukan untuk menilai efek suplementasi vitamin D pada pasien akne. Studi ini dilakukan pada 80 pasien dengan akne dan 80 kontrol sehat. Kadar 25 hydroxyvitamin D atau (25(OH)D diukur, dan data demografik dikumpulkan. Pasien dengan defisiensi vitamin D diterapi dengan cholecalciferol 1000 IU/hari selama 2 bulan. Hasilnya menunjukkan bahwa defisiensi 25 (OH)D dideteksi pada 48% pasien dengan akne, tetapi hanya 22,5% dari kontrol sehat. Kadar 25(OH)D berbanding terbalik dengan tingkat keparahan akne, dan terdapat korelasi negatif yang bermakna dengan lesi inflamasi. Dalam uji selanjutnya, perbaikan lesi inflamasi ditemukan setelah suplementasi vitamin D pada 39 pasien akne dengan defisiensi 25 (OH)D.

Dari studi-studi tersebut disimpulkan bahwa defisiensi vitamin D lebih sering dialami pasien dengan akne, dan kadar 25 (OH)D berbanding terbalik dengan tingkat keparahan akne, khususnya pada pasien dengan lesi inflamasi. Hal ini menunjukkan peranan defisiensi vitamin D pada patogenesis akne. Studi lebih lanjut dengan ukuran sampel yang lebih besar diperlukan untuk mengkonfirmasi hasil studi ini. Evaluasi kadar vitamin D dalam jaringan pada pasien akne juga memerlukan studi lebih lanjut untuk menunjukkan bukti langsung efek vitamin D pada akne. (EKM)

Image : Ilustrasi
Referensi:
1.Lim SK, Ha JM, Lee YH, Lee Y, Seo YJ, Kim CD, et al. Comparison of vitamin D levels in patients with and without acne: A case-control study combined with a randomized controlled trial. PLoS One. 2016 ;11(8):e0161162. doi: 10. 1371/journal.pone. 0161162.
2.Yildizgören MT, Togral AK. Preliminary evidence for vitamin D deficiency in nodulocystic acne. Dermato Endocrinology 2014;6(1).

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it may however on condition that that's what your skin is lacking. By the study of assignment writing service there are several reasons why you may have the skin problem and if its due to a deficiency, well, there's plenty of belongings you may well be deficient in to cause skin problem. nutriment} is thought because of the vitamin of the sun. its what you get naturally from being outside as a result of you can not get terribly plentiful amounts from any foods naturally. due to this milk has added vitamins A and D as a result of its arduous to urge them elsewhere. if you begin to require supplements of vitamins D or perhaps A, BE CAREFUL. you'll be able to poison yourself. initial I might attend a doctor to test out what percentages your blood shows of cholecalciferol and raise if you may take supplements while not symptom your body.
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