Oleh Admin Kalbe Medical pada August 11, 2017 07:30

Secukinumab Efektif untuk Meredakan Gejala Scalp Psoriasis

Psoriasis adalah penyakit kronik pada kulit dengan gejala berupa bercak merah yang bersisik yang dapat disertai juga dengan rasa gatal. Dari segi lokasi, biasanya psoriasis terletak pada bagian ekstensor dari tubuh, misalnya siku, lutut, punggung lengan, kulit kepala, dan lain-lain. Psoriasis dapat mengenai bagian kulit kepala, yang dikenal dengan nama scalp psoriasis.

Scalp psoriasis dapat sangat mengganggu pasien karena kulit kepala adalah bagian tubuh yang terlihat secara langsung, dan sulit untuk ditutupi. Salah satu pengobatan yang telah terbukti efektif untuk psoriasis adalah secukinumab. Namun, secukinumab belum pernah dievaluasi efektivitasnya pada pada pasien scalp psoriasis.


Dr. Feldman dan tim dari USA melakukan sebuah uji klinik untuk mengevaluasi efektivitas secukinumab sebagai pengobatan scalp psoriasis. Mereka melakukan sebuah uji klinik yang diterbitkan di Journal of Dermatology Treatment bulan Juli tahun 2017. Sebanyak 102 pasien scalp psoriasis sedang – berat diacak untuk mendapatkan secukinumab 300 mg atau plasebo. Pasien menjalani pengobatan selama 12 minggu dan hasilnya kemudian dievaluasi dari sisi nyeri, gatal, sisik, serta kualitas hidup.


Hasil yang didapatkan adalah pasien yang mendapatkan secukinumab mengalami perbaikan gejala nyeri (-1,98 vs 0,61); P<0,001, pasien yang mendapatkan secukinumab mengalami perbaikan gejala gatal (-4,07 vs -0,04); P<0,001, pasien yang mendapatkan secukinumab mengalami perbaikan kulit bersisik (-5,76 vs -0,95); P<0,001, dan pasien yang mendapatkan secukinumab mengalami perbaikan kualitas hidup (-39,62 vs -7,91); P<0,001.


Kesimpulan:
Pasien yang mengalami scalp psoriasis sedang – berat akan mendapatkan manfaat dari penggunaan secukinumab 300 mg, berupa: perbaikan gejala nyeri, gejala gatal, gejala bersisik, dan kualitas hidup. (NNO)

Image : Ilustrasi
Referensi:
1.Scalp psoriasis: Causes, symptoms, treatment, and shampoos. WebMD [Internet]. [cited 2017 Jul 30]. Available from: http://www.webmd.com/skin-problems-and-treatments/psoriasis/scalp-psoriasis
2.Feldman SR, Green L, Kimball AB, Siu K, Zhao Y, Herrera V, et al. Secukinumab improves scalp pain, itching, scaling, and quality of life in patients with moderate-to-severe scalp psoriasis. J Dermatol Treat. 2017 Jul 24;1–19.

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