Oleh Admin Kalbe Medical pada August 02, 2017 07:30

Pada Osteoartritis Lutut, 1 Injeksi Stabilized Hyaluronic Acid Lebih Efektif dari 5 Injeksi Standard Hyaluronic Acid

Osteoartritis adalah salah satu penyakit sendi yang paling banyak terjadi, di mana sendi yang paling banyak terkena adalah sendi lutut. Diperkirakan sebanyak 3,8% dari seluruh populasi di dunia mengalami osteoartritis. Faktor risiko osteoartritis adalah usia dan jenis kelamin, di mana wanita lebih rentan untuk mengalami osteoartritis. Pada osteoarthritis terjadi kerusakan pada rawan sendi sehingga pergerakan sendi menjadi terganggu dan juga menjadi terasa nyeri saat bergerak atau bahkan saat tidak bergerak.

Gejala yang dialami oleh orang yang mengalami osteoartritis antara lain: kaku pada sendi, terutama pagi hari, nyeri saat sendi dipakai bergerak, dan pergerakan sendi menjadi terbatas. Ada beberapa pilihan pengobatan osteoartritis mulai dari viskosuplemen sampai tindakan knee-replacement. Salah satu viskosuplemen yang telah terbukti untuk memperbaiki gejala osteoartritis adalah injeksi intraartikuler asam hialuronat. Oleh karena itu, saat ini banyak dokter yang menggunakan injeksi intraartikuler asam hialuronat untuk pasiennya.

Akan tetapi, saat ini sediaan asam hialuronat sangat bervariasi mulai dari yang standar (menyerupai asam hialuronat alami) sampai yang mutakhir yang dikenal dengan NASHA (non-animal stabilized hyaluronic acid) yang memiliki kelebihan berupa lebih stabil dan bertahan lama dalam sendi. Keunggulan dari NASHA adalah karena sifatnya yang stabil, maka hanya membutuhkan sekali penyuntikan untuk bisa memperbaiki gejala sendi sampai 6 bulan atau lebih. Sedangkan asam hialuronat standar, membutuhkan penyuntikkan berulang kali (sampai 5 kali) dan juga efek meredakan gejala pada sendi nya tidak bertahan lama.

Untuk membandingkan mana yang lebih efektif antara NASHA vs asam hialuronat standar, maka dr. Rubio dan tim dari Spanyol melakukan sebuah uji klinik yang diterbitkan di International Journal of Molecular Sciences bulan Februari 2017. Pada uji klinik ini, sebanyak 54 pasien osteoartritis lutut dengan skor Kellgren-Lawrence 2 / 3 dengan skor WOMAC lebih dari 7 diacak untuk menjadi kelompok 1 (mendapatkan NASHA) dan kelompok 2 mendapatkan asam hialuronat standar. Kelompok 1 mendapatkan satu kali injeksi menggunakan teknologi NASHA, sedangkan kelompok 2 mendapatkan 5 kali injeksi (selang satu minggu antar injeksi) dengan menggunakan asam hialuronat standar. Pasien kemudian dievaluasi nyerinya menggunakan skor WOMAC pada minggu ke-1, 2, 4, 8, 12, dan 26.

Hasilnya, dibandingkan dengan asam hialuronat standar, penggunaan NASHA dapat bermanfaat berupa 2 hal yaitu: Pertama, injeksi lebih praktis yaitu cukup satu kali injeksi, dibandingkan dengan asam hialuronat standar yang membutuhkan lima kali injeksi (selang 1 minggu antar injeksi). Kedua, menghasilkan perbaikan skor WOMAC yang lebih baik dibandingkan asam hialuronat standar. (NNO)

Image : Ilustrasi
Referensi:
1.Osteoarthritis: Practice essentials, background, anatomy [Internet]. 2017 Mar 20. Available from: http://emedicine.medscape.com/article/330487-overview#a1
2.Estades-Rubio FJ, Reyes-Martín A, Morales-Marcos V, García-Piriz M, García-Vera JJ, Perán M, et al. Knee viscosupplementation: Cost-effectiveness analysis between stabilized hyaluronic acid in a single injection versus five injections of standard hyaluronic acid. Int J Mol Sci. 2017 Mar 17;18(3).

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10.13linpingping

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Wednesday, October 18, 2017 3:05 PM

MYY


 

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