Oleh Admin Kalbe Medical pada July 14, 2017 07:30

Allergen Immunotherapy Bermanfaat Memperbaiki Gejala Rhinoconjungtivitis Alergi

Rhinoconjungtivitis alergi adalah penyakit peradangan kronik pada hidung, rongga sinus, dan pada konjungtiva dengan gejala berupa hidung tersumbat, hidung gatal, hidung berair, dan mata merah. Penyakit ini merupakan bagian dari penyakit alergi, yang biasanya dicetuskan oleh alergen tertentu, misalnya tungau debu rumah, serbuk sari bunga, dan bulu hewan. Apabila pasien rhinoconjungtivitis mengalami pajanan terhadap alergen yang sensitif, maka sel mast akan melepaskan histamin dan mulailah cascade inflamasi di saluran napas atas. Oleh karena itu, pengobatan rhinoconjungtivitis alergi biasanya berfokus pada meredakan gejala, misalnya menggunakan antihistamin.

Allergen immunotherapy adalah pengobatan yang unik karena tidak hanya meredakan gejala, tetapi bertujuan untuk memodifikasi sensitivitas tubuh pasien terhadap alergen-alergen tertentu, sehingga pasien tidak lagi sensitif terhadap alergen tersebut. Telah ada beberapa uji klinik yang mengevaluasi efektivitas allergen immunotherapy dengan hasil yang bervariasi.


Oleh karena itu, dr. Dhami dan tim dari Inggris melakukan sebuah meta-analisis yang diterbitkan di jurnal Allergy tahun 2017. Meta-analisis ini mengevaluasi data dari 160 uji klinik. Hasilnya didapatkan data bahwa secara umum allergen immunotherapy dapat bermanfaat untuk memperbaiki gejala secara bermakna (standarized mean difference: -0,53, 95%CI -0,63 s/d -0,42) dan mengurangi jumlah kebutuhan medikasi secara bermakna (standarized mean difference -0,49, 95%CI -0,69 s/d -0,30).


Kesimpulan:
Meta-analisis ini mencapai kesimpulan bahwa pada pasien rhinoconjungtivitis alergi, penggunaan allergen immunotherapy bermanfaat untuk memperbaiki gejala serta mengurangi kebutuhan medikasi secara bermakna. (NNO)

Image : Ilustrasi
Referensi:
1.Allergic rhinitis: Practice essentials, background, pathophysiology [Internet]. 2017 Apr 10; Available from: http://emedicine.medscape.com/article/134825-overview
2.The American Academy of Allergy, Asthma & Immunology. Allergy shots (immunotherapy) | AAAAI [Internet]. [cited 2017 Jun 24]. Available from: https://www.aaaai.org/conditions-and-treatments/treatments/allergy-shots-(immunotherapy)
3.Dhami S, Nurmatov U, Arasi S, Khan T, Asaria M, Zaman H, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic review and meta-analysis. Allergy. 2017. doi: 10.1111/all.13201.

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