Oleh Admin Kalbe Medical pada June 15, 2017 07:30

Procyanidin dari GSE Memiliki Efek Menurunkan Asam Urat

Gout merupakan kelainan metabolik yang sering ditemukan pada manusia, dan dilaporkan mengenai lebih dari 2 juta pria dan wanita di US. Gout sering dikaitkan dengan peningkatan kadar asam urat serum, yang menyebabkan deposisi kristal urat pada sendi dan ginjal, yang menyebabkan artritis gout dan nefrolitiasis asam urat. Oleh karena itu, terapi gout memerlukan penggunaan NSAID untuk terapi simptomatik dan penghambat xanthine oxidase untuk mengurangi produksi endogen asam urat. Namun, NSAID dapat menyebabkan efek samping, khususnya pada pasien dengan gangguan ginjal, ulkus peptikum, dan masalah lambung. Allopurinol merupakan penghambat xanthine oxidase yang paling sering digunakan secara klinis untuk terapi gout. Namun, seringkali penggunaannya dibatasi oleh masalah hipersensitivitas, sindrom Steven-Johnson, toksisitas ginjal, dan bahkan nekrosis hati yang fatal.

Suatu studi telah dilakukan untuk menilai efek pemberian suatu antioksidan, yaitu procyanidin dari grape seed extract (GSE) terhadap kadar asam urat serum. Studi ini dilakukan pada model hiperurisemia pada tikus yang dipreterapi dengan oxonate, dan aktivitas xanthine dehydrogenase serta xanthine oxidase pada hati tikus in vivo. Procyanidin, jika diberikan secara oral pada tikus hiperurisemia yang dipre-terapi oxonate, mampu menunjukkan efek hipourisemik yang tergantung dosis. Pada dosis 400 mg/kg selama 3 hari, kadar urat serum pada tikus yang dipre-terapi oxonate tidak berbeda dari tikus normal. Sebagai tambahan, aktivitas xanthine dehydrogenase dan xanthine oxidase hati pada tikus yang diterapi procyanidin ditemukan menurun secara bermakna.

Namun, efek hipourisemik yang ditemukan pada hewan tampaknya tidak paralel dengan perubahan pada aktivitas xanthine dehydrogenase dan xanthine oxidase, yang menunjukkan bahwa procyanidin mungkin berperan melalui mekanisme lain, selain dari penghambatan biasa dari aktivitas enzim tersebut. Lebih lanjut, hewan yang diterapi procyanidin menunjukkan pertumbuhan yang normal, sementara hewan yang diterapi dengan allopurinol menunjukkan pertumbuhan yang lambat.

Hasil studi tersebut menunjukkan bahwa procyanidin dari GSE memiliki aktivitas menurunkan asam urat in vivo. Meskipun mekanisme aksi hipourisemik procyanidin belum sepenuhnya dimengerti, namun senyawa alami ini kemungkinan dapat menjadi alternatif dari allopurinol, atau dalam terapi kombinasi untuk meminimalkan efek samping allopurinol. (EKM)

Image : Ilustrasi
Referensi:
1.Wang Y, Zhu JX, Kong LD, Yang C, Cheng CHK, Zhang X. Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice. Basic Clin Pharmacol Toxicol. 2004;94(5):232-7.
2.Grape seed extract may help to treat gout [Internet]. [cited 2017 May 30]. Available from: http://www.sooperarticles.com/health-fitness-articles/nutrition-articles/grape-seed-extract-may-help-treat-gout-743513.html

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