Oleh Admin Kalbe Medical pada May 05, 2017 07:30

Manfaat Omega-3 pada Dry Eye Syndrome

Dry eye menjadi salah satu alasan tersering yang membuat pasien datang ke klinik mata. Dry eye syndrome (DES) merupakan penyakit multifaktorial, yang mempengaruhi produksi air mata dan permukaan okuler. Keluhan kebanyakan pasien yang berhubungan dengan dry eye meliputi penurunan penglihatan, kesulitan membaca, kesulitan mengendara pada malam hari, dan kesulitan bekerja menggunakan komputer. DES disertai dengan peningkatan osmolaritas tear film, dan peradangan pada permukaan okuler. Meskipun etiopatogenesis DES tidak diketahui dengan pasti, namun diagnosis, pencegahan, dan terapi definitif tetap dapat dilakukan.

Suplementasi air mata buatan merupakan terapi utama pada dry eye. Namun, air mata buatan hanya menghilangkan gejala sementara dan tidak tuntas serta tidak dapat mengembalikan perubahan metaplastik. Oleh karena, DES menjadi subjek utama dalam penelitian yang menarik pada dekade terakhir ini, maka banyak penelitian tentang regimen untuk terapi DES, seperti uridine triphosphate, hormon androgen, air mata buatan yang mengandung rekombinan cytokine growth factor.

Eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), dan alpha linolenic acid (ALA) merupakan 3 bagian dari asam lemak omega-3 yang tidak dapat dibentuk oleh tubuh dan diperlukan suplementasi dalam diet sehari-hari. EPA dan DHA dapat merangsang metabolisme prostaglandin terhadap sistesis prostaglandin anti-inflamasi yang kemudian berkompetisi menghambat jalur arachidonic acid. Inflamasi mempunyai peran utama pada DES. Sebagai contoh, peningkatan konsentrasi sitokin seperti interleuikine-1, interleukine-6, dan tumor necrosis factor-alpha ditemukan dalam tear film pasien dry eye.

Penelitian yang dilakukan oleh Rahal, dkk. dengan tujuan untuk mengevaluasi suplementasi asam lemak omega-3 pada DES. Desain penelitiannya prospective, interventional, acak tersamar ganda dengan plasebo sebagai kontrol. Metodenya adalah dengan mengumpulkan pasien DES sebanyak 264 kemudian diacak manjadi 2 kelompok. Kelompok perlakuan mendapatkan omega-3 500 mg (EPA 325 mg dan DHA 175 mg) yang diminum 2 kali sehari selama 3 bulan, sedangkan kelompok kontrol hanya mendapatkan plasebo. Parameter dinilai sebelum, bulan pertama, kedua, dan ketiga. Parameter yang dinilai jarak pandang, pemeriksaan dengan menggunakan slit lamp, dan keluhan yang dinilai dengan menggunakan skor. Selain itu, juga dilakukan tes Schirmer, tear film break-up time (TBUT). Hasilnya menunjukkan pada kelompok perlakuan terjadi perbaikan keluhan yang bermakna dibandingkan dengan kontrol (p=0,005). Tes Schirmer dan TBUT juga terjadi perbaikan pada kelompok perlakuan (p<0,001).

Simpulan:
Dari penelitian menunjukkan bahwa suplementasi omega-3 dapat memperbaiki keluhan ataupun gejala DES dan memperbaiki tes Schimer. (LAI)

Image : Ilustrasi
Referensi:
1.B Rahul, Kumar P, Kumar M, Mehra N, Mishra A.  A randomized controlled trial of omega-3 fatty acids in dry eye syndrome. Int J Ophthalmol. 2013; 6(6): 811–6. doi:  10.3980/j.issn.2222-3959.2013.06.13
2.Wojtowicz JC, Butovich I, Uchiyama E, Aronowicz J, Agee S, McCulley JP. Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye. 2011;30(3):308-14. doi: 10.1097/ICO.0b013e3181f22e03.

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