Oleh Admin Kalbe Medical pada April 06, 2017 07:30

Suplementasi Vitamin C Bermanfaat Memperbaiki Kontrol Glikemik Pasien Diabetes, Benarkah?

Diabetes melitus adalah penyakit endokrin di mana terjadi penurunan kemampuan tubuh untuk menghasilkan insulin atau respons terhadap insulin, akibatnya terjadi gangguan metabolisme karbohidrat dan peningkatan kadar glukosa di darah dan urin. Ada dua tipe diabetes melitus, yaitu diabetes melitus tipe 1 yang terjadi pada anak dan remaja, serta diabetes tipe 2 yang terjadi pada individu dewasa. 

Salah satu hipotesis mekanisme terjadinya gangguan metabolisme karbohidrat dan glukosa pada pasien diabetes melitus adalah karena terjadi peningkatan radikal bebas serta kurangnya antioksidan untuk mencegah terjadinya stres oksidatif. Oleh karena itu, diduga suplementasi antioksidan seperti vitamin C diduga akan membantu memperbaiki kontrol glikemik pada pasien diabetes melitus. 

Telah ada beberapa uji klinik yang mengevaluasi manfaat suplementasi vitamin C untuk memperbaiki kontrol glikemik pada pasien, dengan hasil yang bervariasi, oleh karena itu dr. Ashor dan tim dari Inggris melakukan sebuah systematic review & metaanalisis yang diterbitkan di jurnal European Journal of Clinical Nutrition tahun 2017. Systematic review & metaanalisis ini mengevaluasi data dari 22 penelitian dengan total pasien sejumlah 937. 

Hasilnya didapatkan bahwa meskipun secara umum suplementasi vitamin C tidak berdampak positif pada kadar glukosa darah, kadar insulin darah, dan kadar HbA1c darah, namun pada subgrup pasien dengan diabetes tipe 2 didapatkan bahwa suplementasi vitamin C menurunkan kadar glukosa secara bermakna (-0,44 mmol/L; 95% CI: -0,81 s/d -0,07; P=0,01). Selain itu, suplementasi vitamin C didapatkan lebih berguna pada pasien diabetes yang mendapat suplemen vitamin C lebih dari 30 hari (-0,53%; 95% CI: -0,79 s/d -0,10; P=0,02). 

Kesimpulan:
Systematic review & metaanalisis ini menyimpulkan bahwa suplementasi vitamin C dapat bermanfaat untuk memperbaiki kontrol glikemik pada dengan diabetes tipe 2. (NNO)

Image : Ilustrasi
Referensi: 
1.Types of diabetes mellitus. WebMD [Internet]. [cited 2017 Mar 28]. Available from: http://www.webmd.com/diabetes/guide/types-of-diabetes-mellitus
2.Ashor AW, Werner AD, Lara J, Willis ND, Mathers JC, Siervo M. Effects of vitamin C supplementation on glycaemic control: A systematic review and meta-analysis of randomised controlled trials. Eur J Clin Nutr. 2017 Mar 15;

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