Oleh admin kalbemed pada October 19, 2018 06:00

Probiotik Berpotensi Membantu Memperbaiki Kadar Gula Darah

Akhir-akhir ini makin banyak studi yang menunjukkan bahwa probiotik dapat merubah flora usus, memperbaiki kolesterol total, dan kadar kolesterol low-density lipoprotein, serta menurunkan glukosa darah serta resistensi insulin. Probiotik khususnya lactobacilli dan bifidobacteria memiliki prospek dlam bioterapi T2DM denagn memperbaiki perubahan komposisi mikrobiota usus.

Sebuah studi metaanalisis dilakukan untuk menilai efek suplementasi probiotik pada profil metabolik pada T2DM. Data pada studi ini diambil dari PubMed, EMBASE, dan Cochrane Library asmpai dengan 12 April 2016. Total 12 randomized controlled trials (RCTs) masuk dalam studi ini, profil lipid (n= 508) dan glukosa darah puasa (FBG) (n=520) dilaporkan pada 9 studi; homeostasis model of assessment for insulin resistance index (HOMA-IR) (n = 368) dan glycosylated hemoglobin (HbA1c) (n = 380) dilaporkan pada 6 studi.

Hasilnya: probitotik dapat menurunkan FBG (SMD -0,61 mmol/L. 95% CI [-0,92 - -0,30]; p = 0,0001). Probiotik dapat meningkatkan high-density lipoprotein-cholesterol (HDL-C) (SMD 0,42 mmol/L. 95% CI [0,08 – 0,76]. p = 0,01). Tidak ada perbedaan bermakna pada low-density lipoprotein-cholesterol (LDL-C), kolesterol total/ total cholesterol (TC), trigliserida (TG), HbA1c dan HOMA-IR antara kelompok terapi dan kelompok kontrol.

Sementara dari analisis sub-grup tidak ada perbedaan bermakna pada spesies tunggal dan multispesies. Penggunaan probiotik selama 8 minggu menunjukkan peningkatan ringan HDL-C, namun tidak ditemukan perbedaan bermakna pada HDL-C pada penggunaan probiotik > 8 minggu.

Secara umum dari hasil peneilitian tersebut peneliti menyimpulkan bawa,  probiotik dapat memperbaiki kontrol glikemik dan metabolisme lipid T2DM. Pemberian probiotik dapat dipertimbangkan sebagai agen baru untuk manajemen glukosa pada T2DM.(AYI)



Image: Ilustrasi
Referensi:
1. Sáez-Lara MJ, Robles-Sanchez C, Ruiz-Ojeda FJ, Plaza-Diaz J, Gil A. Effects of probiotics and synbiotics on obesity, insulin resistance syndrome, type 2 diabetes and non-alcoholic fatty liver disease: A review of human clinical trials. Int J Mol Sci. 2016;17(6). pii: E928. doi: 10.3390/ijms17060928.
2. Li C, Li X, Han H, Cui H, Peng M, Wang G, et al. Effect of probiotics on metabolic profiles in type 2 diabetes mellitus: A meta-analysis of randomized, controlled trials. Medicine (Baltimore). 2016;95(26):e4088. doi: 10.1097/MD.0000000000004088.

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