Oleh admin kalbemed pada October 24, 2018 06:00

Kombinasi Probiotik dan Vitamin C Mampu Mencegah ISPA Anak Prasekolah

Mekanisme kerja penggunaan probiotik pada manajemen URTI (Upper Respiratoy Tract Infection) sebenarnya masih belum jelas. Salah satu penjelasan yang dapat dipertimbangkan adalah kemungkinan adanya kompetisi dari probiotik dengan koloni patogen pada saluran cerna atas.  Atau hipotesis alternatif yaitu probiotik dapat meningkatkan fungsi barier pada tubuh. Sehubungan dengan adanya teori tersebut, pemberian Lactobacillus menunjukkan perbaikan dalam integritas usus yang diukur menggunakan dualsugar permeability test pada anak dengan dermatitis atopi. Beberapa probiotik juga dapat meningkatkan ekspresi dari sekresi mucin pada sel epitel usus. Mucin  yang ada dapat menghalangi perlekatan bakteri patogen untuk mencegah mikroba masuk ke dalam tubuh. Selain itu, probiotik dianggap mempunyai efek imunomodulator, khususnya imunitas cell-mediated yang non-spesifik terhadap berbagai agen infeksius (virus, bakteri, dan jamur) yang sebagian dimediasi oleh natural kill (NK) cell.

Data klinik menunjukkan bahwa jumlah NK cell menurun secara bermakna pada bayi dengan infeksi Respiratory Syncytial Virus (RSV) berat. Sesuai dengan data tersebut, jaringan paru pada anak dengan infeksi RSV yang fatal menunjukkan hampir tidak adanya limfosit CD8+ dan NK cell namun banyak antigen virus. Beberapa studi menunjukkan pemberian Lactobacillus pada hewan dapat meningkatkan aktivitas NK cell dan karena itu dapat mempunyai efek proteksi terhadap infeksi saluran napas. Lactobacillus rhamnosus dalam studi invitro memperlihatkan dapat meningkatkan IFN dan IL-10 yang juga dapat berkontribusi dalam efek imunologis dari pemberian probiotik pada pasien dengan URTI.

Sebuah studi pilot menginvestigasi efikasi pemberian probiotik dikombinasikan dengan vitamin C untuk pencegahan infeksi saluran napas pada anak prasekolah. Studi yang telah dipublikasikan dalam European Journal of Clinical Nutrition tahun 2014 ini menggunakan desain acak, dengan kontrol plasebo pada naik usia 3-6 tahun. 57 subyek anak tersebut diberikan antara 1,25 × 1010 colony-forming units Lactobacillus acidophilusBifidobacterium bifidum, dan Bifidobacterium animalis subsp. lactis ditambahkan 50 mg vitamin C atau mendapat plasebo setiap harinya selama 6 bulan.

Dari studi tersebut menunjukkan hasil bahwa:  terjadi penurunan secara bermakna pada rata-rata insidens infeksi saluran napas atas (URTI; 33%, P=0,002). Jumlah hari dengan gejala  URTI (mean difference: -21,0, 95% confidence interval (CI):-35,9 - -6,0, P=0,006). Rerata insidens tidak masuk preschool (30%, P=0,007) terlihat pada kelompok dengan terapi aktif dibandingkan plasebo. Jumlah hari yang menggunakan antibiotik, pereda nyeri, obat batuk menurun pada kelompok aktif dan mencapai nilai bermakna pada penggunaan obat batuk (mean difference: -6,6. 95% CI: -12,9 - -0,3, P=0,040). Tidak ada perbedaan bermakna pada rasio rerata insidens atau durasi infeksi saluran napas bawah atau kadar sitokin plasma, imunoglobulin Apada saliva atau metabolit urin.

Dari studi ini, penggunaan kombinasi suplementasi probiotik dan vitamin C dapat menghasilkan efek yang menguntungkan dalam pencegahan dan manajemen URTI. (AYN)




Image: Ilustrasi
Referensi:
1. Meneghetti A. Upper Respiratory Tract Infection. Medscape[Internet] 2014 [cited 2014 Okt 17]. Available from:http://emedicine.medscape.com/article/302460-overview#a0101
2. Fashner J, Ericson K, Werner S. Treatment of the common cold in children and adults. Am Fam Physician. 2012;86(2):153-9.
3. Kopp MV, Ankermann T, Härtel C. Clinical potential for the use of probiotics in the management of respiratory conditions and cold- and influenza-like symptoms. Nutrition and Dietary Supplements 2011:3 51–58
4. Garaiova I, Muchová J, Nagyová Z, Wang D, Li JV, Országhová Z, et al. Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. Eur J Clin Nutr. 2014 Sep 10. doi: 10.1038/ejcn.2014.174. [Epub ahead of print]

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## Max Taranov
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«У нас в106.4 кв.м.CHAPTEREyesighРади тебя;На основеСоставитель:MorningОт издателяMinisshСоставитель:Редактор:Издание 1974MargariУкрашениеКнига известногоPettersRondellИздание 1998Для тогоZsolnayЕлочная игрушкаTescomaWilliamХудожник:Книга ГлавногоИз года вВ книге рассматриваетсяНи один изStanley
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L M
## L M
Wednesday, January 09, 2019 6:46 PM

Today we introduce the history of Yamaha outboards For Sale motor.

It’s the new time all over the world. New people, new thing, new atmospherescene.

The speed is very low if we go from the shore to the other side. We swiping the boat

by our hands. We need 10 minutes to ask the boat go only 50 meter.


However, it’s the new time now. Everything can go faster by the new technology.

For example, we can driver the car instead of walking by our feet. We can save more

time to finish the process. Outboard motors for sale is the example for fisher.


As the fisher, they hope that can take least time to catch the most fishes. Then they can earn more money for their families and take more time to do the thing they love. To solve the problem, outboard motor is proposed. With the help of outboard engine, the fishers can catch about 200 fishes in 2 hours. By Yamaha 4 stroke for sale,well begun is half done


With engine, it’s a great progress of human history.

However, it’s not conducive to sustainable development. Human catch more and more fish and the sea environment is worse and worse. With outboard engines For Sale ,the sea is not beautiful and blue again. The fish is less and less.


We would notice our action if we hope the next generation can taste the fish and seethe fish they can’t touch before. We are the special company import and export 300hp outboard for sale. We can supply the 2019 brand new and genuine Yamaha, Suzuki and Honda outboard motor with wholesale price and free shipping.



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